Tree-structured survival analysis of patients with Pseudomonas aeruginosa bacteremia: A multicenter observational cohort study

Young Kyung Yoon, Hyun Ah Kim, Seong Yeol Ryu, Eun Jung Lee, Mi Suk Lee, Jieun Kim, Seong Yeon Park, Kyung Sook Yang, Shin Woo Kim

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    This study aimed to construct a prediction algorithm, which is readily applicable in the clinical setting, to determine the mortality rate for patients with P. aeruginosa bacteremia. A multicenter observational cohort study was performed retrospectively in seven university-affiliated hospitals in Korea from March 2012 to February 2015. In total, 264 adult patients with monomicrobial P. aeruginosa bacteremia were included in the analyses. Among the predictors independently associated with 30-day mortality in the Cox regression model, Pitt bacteremia score >2 and high-risk source of bacteremia were identified as critical nodes in the tree-structured survival analysis. Particularly, the empirical combination therapy was not associated with any survival benefit in the Cox regression model compared to the empirical monotherapy. This study suggests that determining the infection source and evaluating the clinical severity are critical to predict the clinical outcome in patients with P. aeruginosa bacteremia.

    Original languageEnglish
    Pages (from-to)180-187
    Number of pages8
    JournalDiagnostic Microbiology and Infectious Disease
    Volume87
    Issue number2
    DOIs
    Publication statusPublished - 2017 Feb 1

    Keywords

    • Bacteremia
    • Mortality
    • Pseudomonas aeruginosa

    ASJC Scopus subject areas

    • Microbiology (medical)
    • Infectious Diseases

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