Tree-structured survival analysis of patients with Pseudomonas aeruginosa bacteremia: A multicenter observational cohort study

Young Kyung Yoon, Hyun Ah Kim, Seong Yeol Ryu, Eun Jung Lee, Mi Suk Lee, Jieun Kim, Seong Yeon Park, Kyung Sook Yang, Shin Woo Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study aimed to construct a prediction algorithm, which is readily applicable in the clinical setting, to determine the mortality rate for patients with P. aeruginosa bacteremia. A multicenter observational cohort study was performed retrospectively in seven university-affiliated hospitals in Korea from March 2012 to February 2015. In total, 264 adult patients with monomicrobial P. aeruginosa bacteremia were included in the analyses. Among the predictors independently associated with 30-day mortality in the Cox regression model, Pitt bacteremia score >2 and high-risk source of bacteremia were identified as critical nodes in the tree-structured survival analysis. Particularly, the empirical combination therapy was not associated with any survival benefit in the Cox regression model compared to the empirical monotherapy. This study suggests that determining the infection source and evaluating the clinical severity are critical to predict the clinical outcome in patients with P. aeruginosa bacteremia.

Original languageEnglish
Pages (from-to)180-187
Number of pages8
JournalDiagnostic Microbiology and Infectious Disease
Volume87
Issue number2
DOIs
Publication statusPublished - 2017 Feb 1

Keywords

  • Bacteremia
  • Mortality
  • Pseudomonas aeruginosa

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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