@article{cd3ac35fcd7c4f32ad4c6759e662ae67,
title = "Trehalose-6-phosphate signaling regulates thermoresponsive hypocotyl growth in Arabidopsis thaliana",
abstract = "Growth plasticity is a key mechanism by which plants adapt to the ever-changing environmental conditions. Since growth is a high-energy-demanding and irreversible process, it is expected to be regulated by the integration of endogenous energy status as well as environmental conditions. Here, we show that trehalose-6-phosphate (T6P) functions as a sugar signaling molecule that coordinates thermoresponsive hypocotyl growth with endogenous sugar availability. We found that the loss of T6P SYNTHASE 1 (TPS1) in Arabidopsis thaliana impaired high-temperature-mediated hypocotyl growth. Consistently, the activity of PIF4, a transcription factor that positively regulates hypocotyl growth, was compromised in the tps1 mutant. We further show that, in the tps1 mutant, a sugar signaling kinase KIN10 directly phosphorylates and destabilizes PIF4. T6P inhibits KIN10 activity in a GRIK-dependent manner, allowing PIF4 to promote hypocotyl growth at high temperatures. Together, our results demonstrate that T6P determines thermoresponsive growth through the KIN10-PIF4 signaling module. Such regulation of PIF4 by T6P integrates the temperature-signaling pathway with the endogenous sugar status, thus optimizing plant growth response to environmental stresses.",
keywords = "Arabidopsis, PIF4, TPS1, thermomorphogenesis, trehalose-6-phosphate",
author = "Geonhee Hwang and Sara Kim and Cho, {Jae Yong} and Inyup Paik and Kim, {Jeong Il} and Eunkyoo Oh",
note = "Funding Information: We thank Markus Schmid for providing tps1‐2;GVG::TPS1 seeds, Christian Fankhauser for providing pif4‐101 seeds, and Sang‐Dong Yoo for providing KIN10_IN‐OX seeds. This research was supported by grants from Basic Research Lab Program (grant no. NRF‐2017R1A4A1015620) and Basic Science Research Program (grant nos. NRF‐2016R1C1B2008821 and 2017R1A2B4010349) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT, the Next‐Generation BioGreen 21 Program from Rural Development Administration (RDA), Republic of Korea (grant no. PJ01314801), and a Korea University Grant. Funding Information: We thank Markus Schmid for providing tps1-2;GVG::TPS1 seeds, Christian Fankhauser for providing pif4-101 seeds, and Sang-Dong Yoo for providing KIN10_IN-OX seeds. This research was supported by grants from Basic Research Lab Program (grant no. NRF-2017R1A4A1015620) and Basic Science Research Program (grant nos. NRF-2016R1C1B2008821 and 2017R1A2B4010349) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT, the Next-Generation BioGreen 21 Program from Rural Development Administration (RDA), Republic of Korea (grant no. PJ01314801), and a Korea University Grant. Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = oct,
day = "4",
doi = "10.15252/embr.201947828",
language = "English",
volume = "20",
journal = "EMBO Reports",
issn = "1469-221X",
publisher = "Nature Publishing Group",
number = "10",
}