Trends of ulcerative colitis-associated colorectal cancer in Korea

A KASID study

Beom Jin Kim, Suk Kyun Yang, Joo Sung Kim, Yoon Tae Jeen, Hwang Choi, Dong Su Han, Hyo Jong Kim, Won Ho Kim, Jae Yong Kim, Dong Kyung Chang

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background and Aim: The number of patients with ulcerative colitis (UC) in Korea has increased. In addition, the number of patients with colorectal cancer (CRC) associated with UC has also increased. Therefore, this population-based nationwide study was conducted to investigate the incidence of CRC in patients with UC in Korea and compare these results to those of studies conducted in other countries. Methods: The Korean Association for the Study of Intestinal Diseases (KASID) reviewed 7061 cases of UC that occurred between 1970 and 2005 and found a total of 26 cases of CRC. Results: The overall prevalence of CRC in patients with UC was 0.37%. In addition, the estimated cumulative risk of UC-associated CRCs was 0.7% for patients that had UC for 10 years, 7.9% for patients that had UC for 20 years, and 33.2% for patients that had UC for 30 years. The mean age at the time of diagnosis with CRC was 49.6 years, and the mean duration of UC prior to the development of CRC was 11.5 years. Most UC-associated CRCs were diagnosed after they were already in advanced stages; however, the stage at diagnosis was lower in patients that had good compliance with medical treatment. Conclusion: The cumulative incidence of UC-associated CRCs in Korea was found to be comparable to that of western countries. The overall occurrence of UC-associated CRC in Korea may be growing, therefore, intensive surveillance colonoscopy and constructive chemoprevention should be encouraged to enable early detection and treatment of UC-associated CRCs in Korea.

Original languageEnglish
Pages (from-to)667-671
Number of pages5
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume24
Issue number4
DOIs
Publication statusPublished - 2009 Jan 1

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Intestinal Diseases
Korea
Ulcerative Colitis
Colorectal Neoplasms
Incidence
Chemoprevention
Colonoscopy

Keywords

  • Incidence
  • Korea
  • Prevalence
  • UC-associated CRC
  • Ulcerative colitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Trends of ulcerative colitis-associated colorectal cancer in Korea : A KASID study. / Kim, Beom Jin; Yang, Suk Kyun; Kim, Joo Sung; Jeen, Yoon Tae; Choi, Hwang; Han, Dong Su; Kim, Hyo Jong; Kim, Won Ho; Kim, Jae Yong; Chang, Dong Kyung.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 24, No. 4, 01.01.2009, p. 667-671.

Research output: Contribution to journalArticle

Kim, Beom Jin ; Yang, Suk Kyun ; Kim, Joo Sung ; Jeen, Yoon Tae ; Choi, Hwang ; Han, Dong Su ; Kim, Hyo Jong ; Kim, Won Ho ; Kim, Jae Yong ; Chang, Dong Kyung. / Trends of ulcerative colitis-associated colorectal cancer in Korea : A KASID study. In: Journal of Gastroenterology and Hepatology (Australia). 2009 ; Vol. 24, No. 4. pp. 667-671.
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AU - Jeen, Yoon Tae

AU - Choi, Hwang

AU - Han, Dong Su

AU - Kim, Hyo Jong

AU - Kim, Won Ho

AU - Kim, Jae Yong

AU - Chang, Dong Kyung

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AB - Background and Aim: The number of patients with ulcerative colitis (UC) in Korea has increased. In addition, the number of patients with colorectal cancer (CRC) associated with UC has also increased. Therefore, this population-based nationwide study was conducted to investigate the incidence of CRC in patients with UC in Korea and compare these results to those of studies conducted in other countries. Methods: The Korean Association for the Study of Intestinal Diseases (KASID) reviewed 7061 cases of UC that occurred between 1970 and 2005 and found a total of 26 cases of CRC. Results: The overall prevalence of CRC in patients with UC was 0.37%. In addition, the estimated cumulative risk of UC-associated CRCs was 0.7% for patients that had UC for 10 years, 7.9% for patients that had UC for 20 years, and 33.2% for patients that had UC for 30 years. The mean age at the time of diagnosis with CRC was 49.6 years, and the mean duration of UC prior to the development of CRC was 11.5 years. Most UC-associated CRCs were diagnosed after they were already in advanced stages; however, the stage at diagnosis was lower in patients that had good compliance with medical treatment. Conclusion: The cumulative incidence of UC-associated CRCs in Korea was found to be comparable to that of western countries. The overall occurrence of UC-associated CRC in Korea may be growing, therefore, intensive surveillance colonoscopy and constructive chemoprevention should be encouraged to enable early detection and treatment of UC-associated CRCs in Korea.

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