TRIF mediates toll-like receptor 2-dependent inflammatory responses to borrelia burgdorferi

Tanja Petnicki-Ocwieja, Erin Chung, David I. Acosta, Laurie T. Ramos, Ok Shin, Sanjukta Ghosh, Lester Kobzik, Xin Li, Linden T. Hua

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

TRIF is an adaptor molecule important in transducing signals from intracellularly signaling Toll-like receptor 3 (TLR3) and TLR4. Recently, TLR2 was found to signal from intracellular compartments.Using a synthetic ligand for TLR2/1 heterodimers, as well as Borrelia burgdorferi, which is a strong activator of TLR2/1, we found that TLR2 signaling can utilize TRIF. Unlike TRIF signaling by other TLRs, TLR2-mediated TRIF signaling is dependent on the presence of another adaptor molecule, MyD88. However, unlike MyD88 deficiency, TRIF deficiency does not result in diminished control of infection with B. burgdorferi in a murine model of disease. This appears to be due to the effects of MyD88 on phagocytosis via scavenger receptors, such as MARCO, which are not affected by the loss of TRIF. In mice, TRIF deficiency did have an effect on the production of inflammatory cytokines, suggesting that regulation of inflammatory cytokines and control of bacterial growth may be uncoupled, in part through transduction of TLR2 signaling through TRIF.

Original languageEnglish
Pages (from-to)402-410
Number of pages9
JournalInfection and Immunity
Volume81
Issue number2
DOIs
Publication statusPublished - 2013 Feb 1
Externally publishedYes

Fingerprint

Toll-Like Receptor 2
Borrelia burgdorferi
Toll-Like Receptor 3
Cytokines
Scavenger Receptors
Infection Control
Phagocytosis
Ligands
Growth

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Parasitology
  • Infectious Diseases

Cite this

Petnicki-Ocwieja, T., Chung, E., Acosta, D. I., Ramos, L. T., Shin, O., Ghosh, S., ... Hua, L. T. (2013). TRIF mediates toll-like receptor 2-dependent inflammatory responses to borrelia burgdorferi. Infection and Immunity, 81(2), 402-410. https://doi.org/10.1128/IAI.00890-12

TRIF mediates toll-like receptor 2-dependent inflammatory responses to borrelia burgdorferi. / Petnicki-Ocwieja, Tanja; Chung, Erin; Acosta, David I.; Ramos, Laurie T.; Shin, Ok; Ghosh, Sanjukta; Kobzik, Lester; Li, Xin; Hua, Linden T.

In: Infection and Immunity, Vol. 81, No. 2, 01.02.2013, p. 402-410.

Research output: Contribution to journalArticle

Petnicki-Ocwieja, T, Chung, E, Acosta, DI, Ramos, LT, Shin, O, Ghosh, S, Kobzik, L, Li, X & Hua, LT 2013, 'TRIF mediates toll-like receptor 2-dependent inflammatory responses to borrelia burgdorferi', Infection and Immunity, vol. 81, no. 2, pp. 402-410. https://doi.org/10.1128/IAI.00890-12
Petnicki-Ocwieja, Tanja ; Chung, Erin ; Acosta, David I. ; Ramos, Laurie T. ; Shin, Ok ; Ghosh, Sanjukta ; Kobzik, Lester ; Li, Xin ; Hua, Linden T. / TRIF mediates toll-like receptor 2-dependent inflammatory responses to borrelia burgdorferi. In: Infection and Immunity. 2013 ; Vol. 81, No. 2. pp. 402-410.
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