Triple-conjugated photo-/temperature-/pH-sensitive chitosan with an intelligent response for bioengineering applications

Quang Tuan Che, Korakot Charoensri, Jeong Wook Seo, Minh Hiep Nguyen, Goo Jang, Hojae Bae, Hyun Jin Park

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Hybrid-crosslinked systems, which can be formed using heat and visible light, are significant for improving the stability of hydrogels under physiological conditions. However, several challenges for their practical application remain, such as shrinking under culture medium conditions or the neutral pH in the small intestine. Therefore, a multi-sensitive hydrogel with response to external conditions has been designed and prepared, which could be employed as a biopolymer ink formulation for three-dimensional printing in bioengineering applications. When exposed to body temperature and visible light, the N-succinyl hydroxybutyl methacrylated chitosan (NS-HBC-MA) undergoes a sol-gel phase transition. The NS-HBC-MA hydrogel exhibits pH-responsive swelling, effectively preventing shrinkage at a neutral pH. Furthermore, NS-HBC-MA hydrogel demonstrates excellent biocompatibility and biodegradability. This study demonstrates that the NS-HBC-MA hydrogel has significant potential for various applications, including wound healing, delivery systems, and tissue engineering.

Original languageEnglish
Article number120066
JournalCarbohydrate Polymers
Publication statusPublished - 2022 Dec 15


  • 3D printing
  • Chitosan
  • Hydroxybutylation
  • Methacrylation
  • Multi-sensitive hydrogel
  • Succinylation

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry


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