Triple negative breast cancer in Korea-distinct biology with different impact of prognostic factors on survival

Jung Ah Lee, Kwan Il Kim, Jeoung Won Bae, Young Hoon Jung, Hyonggin An, Eun Sook Lee

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

We analyzed breast cancer subtypes using Korean Breast Cancer Society Registration Program data to compare clinical features and prognosis for triple-negative breast cancer (TNBC). A cohort of 26,767 breast cancer patients were divided in four groups: luminal A (ER+ and/or PR+, HER2-), luminal B (ER+ and/or PR+ HER2+), HER2+ (ER-, PR-, HER2+), and triple-negative (ER-, PR-, HER2-). Clinicopathologic factors were evaluated. The luminal A (14,437 patients, 53.9%) subtype was the largest in our study. Compared with luminal A subtype, TNBC correlated with younger age, more aggressive characteristics and poor overall survival and breast cancer-specific survival. The hazard rate showed a peak at 24 months for the TNBC subtype, but after 60 months, risk was similar to that of the luminal A subtype. Higher T, N stage and histologic grade, and lymphatic and vascular invasion showed poor prognosis in TNBC patients, but on multivariate analysis only histologic grade and ki-67 status were related. Young age was related to poor prognosis in the luminal A subtype, however, age was not related to prognosis in the TNBC subtype. Of the 5,586 TNBC patients, 282 patients (7.11%) expired within 3 years of diagnosis. T and N stage and grade were significantly associated with prognosis on multivariate analysis. TNBC subtype is characterized by younger age with poorer outcome. However, younger age is not related to prognosis, and mortality risk decreases to that of the luminal A subtype, which is known to have the best prognosis after a few years.

Original languageEnglish
Pages (from-to)177-187
Number of pages11
JournalBreast Cancer Research and Treatment
Volume123
Issue number1
DOIs
Publication statusPublished - 2010 Aug 1

Fingerprint

Triple Negative Breast Neoplasms
Korea
Survival
Breast Neoplasms
Multivariate Analysis
Blood Vessels
Mortality

Keywords

  • Breast cancer
  • Prognosis
  • Survival
  • Triple negative breast cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Triple negative breast cancer in Korea-distinct biology with different impact of prognostic factors on survival. / Lee, Jung Ah; Kim, Kwan Il; Bae, Jeoung Won; Jung, Young Hoon; An, Hyonggin; Lee, Eun Sook.

In: Breast Cancer Research and Treatment, Vol. 123, No. 1, 01.08.2010, p. 177-187.

Research output: Contribution to journalArticle

Lee, Jung Ah ; Kim, Kwan Il ; Bae, Jeoung Won ; Jung, Young Hoon ; An, Hyonggin ; Lee, Eun Sook. / Triple negative breast cancer in Korea-distinct biology with different impact of prognostic factors on survival. In: Breast Cancer Research and Treatment. 2010 ; Vol. 123, No. 1. pp. 177-187.
@article{a9694596872e435b876793c78dc7ef43,
title = "Triple negative breast cancer in Korea-distinct biology with different impact of prognostic factors on survival",
abstract = "We analyzed breast cancer subtypes using Korean Breast Cancer Society Registration Program data to compare clinical features and prognosis for triple-negative breast cancer (TNBC). A cohort of 26,767 breast cancer patients were divided in four groups: luminal A (ER+ and/or PR+, HER2-), luminal B (ER+ and/or PR+ HER2+), HER2+ (ER-, PR-, HER2+), and triple-negative (ER-, PR-, HER2-). Clinicopathologic factors were evaluated. The luminal A (14,437 patients, 53.9{\%}) subtype was the largest in our study. Compared with luminal A subtype, TNBC correlated with younger age, more aggressive characteristics and poor overall survival and breast cancer-specific survival. The hazard rate showed a peak at 24 months for the TNBC subtype, but after 60 months, risk was similar to that of the luminal A subtype. Higher T, N stage and histologic grade, and lymphatic and vascular invasion showed poor prognosis in TNBC patients, but on multivariate analysis only histologic grade and ki-67 status were related. Young age was related to poor prognosis in the luminal A subtype, however, age was not related to prognosis in the TNBC subtype. Of the 5,586 TNBC patients, 282 patients (7.11{\%}) expired within 3 years of diagnosis. T and N stage and grade were significantly associated with prognosis on multivariate analysis. TNBC subtype is characterized by younger age with poorer outcome. However, younger age is not related to prognosis, and mortality risk decreases to that of the luminal A subtype, which is known to have the best prognosis after a few years.",
keywords = "Breast cancer, Prognosis, Survival, Triple negative breast cancer",
author = "Lee, {Jung Ah} and Kim, {Kwan Il} and Bae, {Jeoung Won} and Jung, {Young Hoon} and Hyonggin An and Lee, {Eun Sook}",
year = "2010",
month = "8",
day = "1",
doi = "10.1007/s10549-010-0998-5",
language = "English",
volume = "123",
pages = "177--187",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Triple negative breast cancer in Korea-distinct biology with different impact of prognostic factors on survival

AU - Lee, Jung Ah

AU - Kim, Kwan Il

AU - Bae, Jeoung Won

AU - Jung, Young Hoon

AU - An, Hyonggin

AU - Lee, Eun Sook

PY - 2010/8/1

Y1 - 2010/8/1

N2 - We analyzed breast cancer subtypes using Korean Breast Cancer Society Registration Program data to compare clinical features and prognosis for triple-negative breast cancer (TNBC). A cohort of 26,767 breast cancer patients were divided in four groups: luminal A (ER+ and/or PR+, HER2-), luminal B (ER+ and/or PR+ HER2+), HER2+ (ER-, PR-, HER2+), and triple-negative (ER-, PR-, HER2-). Clinicopathologic factors were evaluated. The luminal A (14,437 patients, 53.9%) subtype was the largest in our study. Compared with luminal A subtype, TNBC correlated with younger age, more aggressive characteristics and poor overall survival and breast cancer-specific survival. The hazard rate showed a peak at 24 months for the TNBC subtype, but after 60 months, risk was similar to that of the luminal A subtype. Higher T, N stage and histologic grade, and lymphatic and vascular invasion showed poor prognosis in TNBC patients, but on multivariate analysis only histologic grade and ki-67 status were related. Young age was related to poor prognosis in the luminal A subtype, however, age was not related to prognosis in the TNBC subtype. Of the 5,586 TNBC patients, 282 patients (7.11%) expired within 3 years of diagnosis. T and N stage and grade were significantly associated with prognosis on multivariate analysis. TNBC subtype is characterized by younger age with poorer outcome. However, younger age is not related to prognosis, and mortality risk decreases to that of the luminal A subtype, which is known to have the best prognosis after a few years.

AB - We analyzed breast cancer subtypes using Korean Breast Cancer Society Registration Program data to compare clinical features and prognosis for triple-negative breast cancer (TNBC). A cohort of 26,767 breast cancer patients were divided in four groups: luminal A (ER+ and/or PR+, HER2-), luminal B (ER+ and/or PR+ HER2+), HER2+ (ER-, PR-, HER2+), and triple-negative (ER-, PR-, HER2-). Clinicopathologic factors were evaluated. The luminal A (14,437 patients, 53.9%) subtype was the largest in our study. Compared with luminal A subtype, TNBC correlated with younger age, more aggressive characteristics and poor overall survival and breast cancer-specific survival. The hazard rate showed a peak at 24 months for the TNBC subtype, but after 60 months, risk was similar to that of the luminal A subtype. Higher T, N stage and histologic grade, and lymphatic and vascular invasion showed poor prognosis in TNBC patients, but on multivariate analysis only histologic grade and ki-67 status were related. Young age was related to poor prognosis in the luminal A subtype, however, age was not related to prognosis in the TNBC subtype. Of the 5,586 TNBC patients, 282 patients (7.11%) expired within 3 years of diagnosis. T and N stage and grade were significantly associated with prognosis on multivariate analysis. TNBC subtype is characterized by younger age with poorer outcome. However, younger age is not related to prognosis, and mortality risk decreases to that of the luminal A subtype, which is known to have the best prognosis after a few years.

KW - Breast cancer

KW - Prognosis

KW - Survival

KW - Triple negative breast cancer

UR - http://www.scopus.com/inward/record.url?scp=77955770298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955770298&partnerID=8YFLogxK

U2 - 10.1007/s10549-010-0998-5

DO - 10.1007/s10549-010-0998-5

M3 - Article

VL - 123

SP - 177

EP - 187

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 1

ER -