Triplet Graph Convolutional Network for Multi-scale Analysis of Functional Connectivity Using Functional MRI

Dongren Yao, Mingxia Liu, Mingliang Wang, Chunfeng Lian, Jie Wei, Li Sun, Jing Sui, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Brain functional connectivity (FC) derived from resting-state functional MRI (rs-fMRI) data has become a powerful approach to measure and map brain activity. Using fMRI data, graph convolutional network (GCN) has recently shown its superiority in learning discriminative representations of brain FC networks. However, existing studies typically utilize one specific template to partition the brain into multiple regions-of-interest (ROIs) for constructing FCs, which may limit the analysis to a single spatial scale (i.e., a fixed graph) determined by the template. Also, previous methods usually ignore the underlying high-order (e.g., triplet) association among subjects. To this end, we propose a multi-scale triplet graph convolutional network (MTGCN) for brain functional connectivity analysis with rs-fMRI data. Specifically, we first employ multi-scale templates for coarse-to-fine ROI parcellation to construct multi-scale FCs for each subject. We then develop a triplet GCN (TGCN) model to learn multi-scale graph representations of brain FC networks, followed by a weighted fusion scheme for classification. Experimental results on 1,218 subjects suggest the efficacy or our method.

Original languageEnglish
Title of host publicationGraph Learning in Medical Imaging - 1st International Workshop, GLMI 2019, held in Conjunction with MICCAI 2019, Proceedings
EditorsDaoqiang Zhang, Luping Zhou, Biao Jie, Mingxia Liu
PublisherSpringer
Pages70-78
Number of pages9
ISBN (Print)9783030358167
DOIs
Publication statusPublished - 2019 Jan 1
Externally publishedYes
Event1st International Workshop on Graph Learning in Medical Imaging, GLMI 2019 held in conjunction with the 22nd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2019 - Shenzhen, China
Duration: 2019 Oct 172019 Oct 17

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11849 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference1st International Workshop on Graph Learning in Medical Imaging, GLMI 2019 held in conjunction with the 22nd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2019
CountryChina
CityShenzhen
Period19/10/1719/10/17

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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  • Cite this

    Yao, D., Liu, M., Wang, M., Lian, C., Wei, J., Sun, L., Sui, J., & Shen, D. (2019). Triplet Graph Convolutional Network for Multi-scale Analysis of Functional Connectivity Using Functional MRI. In D. Zhang, L. Zhou, B. Jie, & M. Liu (Eds.), Graph Learning in Medical Imaging - 1st International Workshop, GLMI 2019, held in Conjunction with MICCAI 2019, Proceedings (pp. 70-78). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11849 LNCS). Springer. https://doi.org/10.1007/978-3-030-35817-4_9