Trisomy 1q in a patient with severe aplastic anemia

Prodromos Angelidis, Kiarash Kojouri, Ji-Yun Lee, William Kern, John J. Mulvihill, Shibo Li

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Aplastic anemia is a rare, serious disease characterized by hypocellular bone marrow and pancytopenia in the peripheral blood. Most cases are acquired, idiopathic, and without gross cytogenetic abnormalities. A few chromosome abnormalities have recurred among a small subset of patients, most commonly trisomy 8 and monosomy 7. Some of these chromosome abnormalities have prognostic and therapeutic significance, although for most the clinical relevance is not known. We present the case of a 40-year-old man with idiopathic severe aplastic anemia in bone marrow cells with trisomy of the whole long arm of chromosome 1 due to an unbalanced translocation between chromosomes 1 and 15 at breakpoints of q10 and 15q10. This clonal abnormality (which, to our knowledge, has not been previously reported in a patient with aplastic anemia) suggests that genes on 1q may be involved in marrow aplasia.

Original languageEnglish
Pages (from-to)73-75
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume169
Issue number1
DOIs
Publication statusPublished - 2006 Aug 1
Externally publishedYes

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Aplastic Anemia
Trisomy
Chromosome Aberrations
Chromosomes, Human, Pair 1
Bone Marrow
Chromosomes, Human, Pair 15
Pancytopenia
Rare Diseases
Bone Marrow Cells
Genes
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Trisomy 1q in a patient with severe aplastic anemia. / Angelidis, Prodromos; Kojouri, Kiarash; Lee, Ji-Yun; Kern, William; Mulvihill, John J.; Li, Shibo.

In: Cancer Genetics and Cytogenetics, Vol. 169, No. 1, 01.08.2006, p. 73-75.

Research output: Contribution to journalArticle

Angelidis, P, Kojouri, K, Lee, J-Y, Kern, W, Mulvihill, JJ & Li, S 2006, 'Trisomy 1q in a patient with severe aplastic anemia', Cancer Genetics and Cytogenetics, vol. 169, no. 1, pp. 73-75. https://doi.org/10.1016/j.cancergencyto.2006.03.014
Angelidis, Prodromos ; Kojouri, Kiarash ; Lee, Ji-Yun ; Kern, William ; Mulvihill, John J. ; Li, Shibo. / Trisomy 1q in a patient with severe aplastic anemia. In: Cancer Genetics and Cytogenetics. 2006 ; Vol. 169, No. 1. pp. 73-75.
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