Tristetraprolin inhibits the growth of human glioma cells through downregulation of urokinase plasminogen activator/urokinase plasminogen activator receptor mRNAs

Jinhyun Ryu, Nal Ae Yoon, Yeon Kyung Lee, Joo Yeon Jeong, Seokmin Kang, Hyemin Seong, Jungil Choi, Nammi Park, Nayoung Kim, Wha Ja Cho, Sun Ha Paek, Gyeong Jae Cho, Wan Sung Choi, Jae-Yong Park, Jeong Woo Park, Sang Soo Kang

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8 Citations (Scopus)

Abstract

Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) play a major role in the infiltrative growth of glioblastoma. Downregulatoion of the uPA and uPAR has been reported to inhibit the growth glioblastoma. Here, we demonstrate that tristetraprolin (TTP) inhibits the growth of U87MG human glioma cells through downregulation of uPA and uPAR. Our results show that expression level of TTP is inversely correlated with those of uPA and uPAR in human glioma cells and tissues. TTP binds to the AU-rich elements within the 3’ untranslated regions of uPA and uPAR and overexpression of TTP decreased the expression of uPA and uPAR through enhancing the degradation of their mRNAs. In addition, overexpression of TTP inhibited the growth and invasion of U87MG cells. Our findings implicate that TTP can be used as a promising therapeutic target to treat human glioma.

Original languageEnglish
Pages (from-to)156-162
Number of pages7
JournalMolecules and cells
Volume38
Issue number2
DOIs
Publication statusPublished - 2014 Dec 30

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Keywords

  • Glioma
  • TTP
  • UPA
  • UPAR

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ryu, J., Yoon, N. A., Lee, Y. K., Jeong, J. Y., Kang, S., Seong, H., Choi, J., Park, N., Kim, N., Cho, W. J., Paek, S. H., Cho, G. J., Choi, W. S., Park, J-Y., Park, J. W., & Kang, S. S. (2014). Tristetraprolin inhibits the growth of human glioma cells through downregulation of urokinase plasminogen activator/urokinase plasminogen activator receptor mRNAs. Molecules and cells, 38(2), 156-162. https://doi.org/10.14348/molcells.2015.2259