Tristetraprolin inhibits the growth of human glioma cells through downregulation of urokinase plasminogen activator/urokinase plasminogen activator receptor mRNAs

Jinhyun Ryu, Nal Ae Yoon, Yeon Kyung Lee, Joo Yeon Jeong, Seokmin Kang, Hyemin Seong, Jungil Choi, Nammi Park, Nayoung Kim, Wha Ja Cho, Sun Ha Paek, Gyeong Jae Cho, Wan Sung Choi, Jae-Yong Park, Jeong Woo Park, Sang Soo Kang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) play a major role in the infiltrative growth of glioblastoma. Downregulatoion of the uPA and uPAR has been reported to inhibit the growth glioblastoma. Here, we demonstrate that tristetraprolin (TTP) inhibits the growth of U87MG human glioma cells through downregulation of uPA and uPAR. Our results show that expression level of TTP is inversely correlated with those of uPA and uPAR in human glioma cells and tissues. TTP binds to the AU-rich elements within the 3’ untranslated regions of uPA and uPAR and overexpression of TTP decreased the expression of uPA and uPAR through enhancing the degradation of their mRNAs. In addition, overexpression of TTP inhibited the growth and invasion of U87MG cells. Our findings implicate that TTP can be used as a promising therapeutic target to treat human glioma.

Original languageEnglish
Pages (from-to)156-162
Number of pages7
JournalMolecules and cells
Volume38
Issue number2
DOIs
Publication statusPublished - 2014 Dec 30

Fingerprint

Tristetraprolin
Urokinase Plasminogen Activator Receptors
Plasminogen Activators
Urokinase-Type Plasminogen Activator
Glioma
Down-Regulation
Messenger RNA
Growth
Glioblastoma
AU Rich Elements
RNA Stability
3' Untranslated Regions

Keywords

  • Glioma
  • TTP
  • UPA
  • UPAR

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tristetraprolin inhibits the growth of human glioma cells through downregulation of urokinase plasminogen activator/urokinase plasminogen activator receptor mRNAs. / Ryu, Jinhyun; Yoon, Nal Ae; Lee, Yeon Kyung; Jeong, Joo Yeon; Kang, Seokmin; Seong, Hyemin; Choi, Jungil; Park, Nammi; Kim, Nayoung; Cho, Wha Ja; Paek, Sun Ha; Cho, Gyeong Jae; Choi, Wan Sung; Park, Jae-Yong; Park, Jeong Woo; Kang, Sang Soo.

In: Molecules and cells, Vol. 38, No. 2, 30.12.2014, p. 156-162.

Research output: Contribution to journalArticle

Ryu, J, Yoon, NA, Lee, YK, Jeong, JY, Kang, S, Seong, H, Choi, J, Park, N, Kim, N, Cho, WJ, Paek, SH, Cho, GJ, Choi, WS, Park, J-Y, Park, JW & Kang, SS 2014, 'Tristetraprolin inhibits the growth of human glioma cells through downregulation of urokinase plasminogen activator/urokinase plasminogen activator receptor mRNAs', Molecules and cells, vol. 38, no. 2, pp. 156-162. https://doi.org/10.14348/molcells.2015.2259
Ryu, Jinhyun ; Yoon, Nal Ae ; Lee, Yeon Kyung ; Jeong, Joo Yeon ; Kang, Seokmin ; Seong, Hyemin ; Choi, Jungil ; Park, Nammi ; Kim, Nayoung ; Cho, Wha Ja ; Paek, Sun Ha ; Cho, Gyeong Jae ; Choi, Wan Sung ; Park, Jae-Yong ; Park, Jeong Woo ; Kang, Sang Soo. / Tristetraprolin inhibits the growth of human glioma cells through downregulation of urokinase plasminogen activator/urokinase plasminogen activator receptor mRNAs. In: Molecules and cells. 2014 ; Vol. 38, No. 2. pp. 156-162.
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