Trophoblast glycoprotein is a new candidate gene for Parkinson’s disease

Sanghyun Park, Jeong Eun Yoo, Gyu Bum Yeon, Jin Hee Kim, Jae Souk Lee, Sung Kyoung Choi, Young Gi Hwang, Chan Wook Park, Myung Soo Cho, Jongwan Kim, Dokyun Na, Hyung Wook Kim, Dae Sung Kim, Dong Wook Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Parkinson’s disease (PD) is a movement disorder caused by progressive degeneration of the midbrain dopaminergic (mDA) neurons in the substantia nigra pars compacta (SNc). Despite intense research efforts over the past decades, the etiology of PD remains largely unknown. Here, we discovered the involvement of trophoblast glycoprotein (Tpbg) in the development of PD-like phenotypes in mice. Tpbg expression was detected in the ventral midbrain during embryonic development and in mDA neurons in adulthood. Genetic ablation of Tpbg resulted in mild degeneration of mDA neurons in aged mice (12–14 months) with behavioral deficits reminiscent of PD symptoms. Through in silico analysis, we predicted potential TPBG-interacting partners whose functions were relevant to PD pathogenesis; this result was substantiated by transcriptomic analysis of the SNc of aged Tpbg knockout mice. These findings suggest that Tpbg is a new candidate gene associated with PD and provide a new insight into PD pathogenesis.

Original languageEnglish
Article number110
Journalnpj Parkinson's Disease
Volume7
Issue number1
DOIs
Publication statusPublished - 2021 Dec

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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