Truxillic acid derivatives act as peroxisome proliferator-activated receptor γ activators

Ramona Steri, Matthias Rupp, Ewgenij Proschak, Timon Schroeter, Heiko Zettl, Katja Hansen, Oliver Schwarz, Lutz Müller-Kuhrt, Klaus Robert Müller, Gisbert Schneider, Manfred Schubert-Zsilavecz

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In previous studies, we identified a truxillic acid derivative as selective activator of the peroxisome proliferator-activated receptor γ, which is a member of the nuclear receptor family and acts as ligand-activated transcription factor of genes involved in glucose metabolism. Herein we present the structure-activity relationships of 16 truxillic acid derivatives, investigated by a cell-based reporter gene assay guided by molecular docking analysis.

Original languageEnglish
Pages (from-to)2920-2923
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number9
DOIs
Publication statusPublished - 2010 May 1
Externally publishedYes

Keywords

  • Molecular docking
  • Nuclear receptors
  • PPARγ
  • Reporter gene assay
  • Structure-activity relationships
  • Truxillic acid derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Steri, R., Rupp, M., Proschak, E., Schroeter, T., Zettl, H., Hansen, K., Schwarz, O., Müller-Kuhrt, L., Müller, K. R., Schneider, G., & Schubert-Zsilavecz, M. (2010). Truxillic acid derivatives act as peroxisome proliferator-activated receptor γ activators. Bioorganic and Medicinal Chemistry Letters, 20(9), 2920-2923. https://doi.org/10.1016/j.bmcl.2010.03.026