Truxillic acid derivatives act as peroxisome proliferator-activated receptor γ activators

Ramona Steri, Matthias Rupp, Ewgenij Proschak, Timon Schroeter, Heiko Zettl, Katja Hansen, Oliver Schwarz, Lutz Müller-Kuhrt, Klaus Muller, Gisbert Schneider, Manfred Schubert-Zsilavecz

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In previous studies, we identified a truxillic acid derivative as selective activator of the peroxisome proliferator-activated receptor γ, which is a member of the nuclear receptor family and acts as ligand-activated transcription factor of genes involved in glucose metabolism. Herein we present the structure-activity relationships of 16 truxillic acid derivatives, investigated by a cell-based reporter gene assay guided by molecular docking analysis.

Original languageEnglish
Pages (from-to)2920-2923
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number9
DOIs
Publication statusPublished - 2010 May 1
Externally publishedYes

Fingerprint

Peroxisome Proliferator-Activated Receptors
Molecular Docking Simulation
Genes
Derivatives
Structure-Activity Relationship
Cytoplasmic and Nuclear Receptors
Nuclear Family
Reporter Genes
Metabolism
Assays
Transcription Factors
Ligands
Glucose
truxillic acid

Keywords

  • Molecular docking
  • Nuclear receptors
  • PPARγ
  • Reporter gene assay
  • Structure-activity relationships
  • Truxillic acid derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Steri, R., Rupp, M., Proschak, E., Schroeter, T., Zettl, H., Hansen, K., ... Schubert-Zsilavecz, M. (2010). Truxillic acid derivatives act as peroxisome proliferator-activated receptor γ activators. Bioorganic and Medicinal Chemistry Letters, 20(9), 2920-2923. https://doi.org/10.1016/j.bmcl.2010.03.026

Truxillic acid derivatives act as peroxisome proliferator-activated receptor γ activators. / Steri, Ramona; Rupp, Matthias; Proschak, Ewgenij; Schroeter, Timon; Zettl, Heiko; Hansen, Katja; Schwarz, Oliver; Müller-Kuhrt, Lutz; Muller, Klaus; Schneider, Gisbert; Schubert-Zsilavecz, Manfred.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 9, 01.05.2010, p. 2920-2923.

Research output: Contribution to journalArticle

Steri, R, Rupp, M, Proschak, E, Schroeter, T, Zettl, H, Hansen, K, Schwarz, O, Müller-Kuhrt, L, Muller, K, Schneider, G & Schubert-Zsilavecz, M 2010, 'Truxillic acid derivatives act as peroxisome proliferator-activated receptor γ activators', Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 9, pp. 2920-2923. https://doi.org/10.1016/j.bmcl.2010.03.026
Steri, Ramona ; Rupp, Matthias ; Proschak, Ewgenij ; Schroeter, Timon ; Zettl, Heiko ; Hansen, Katja ; Schwarz, Oliver ; Müller-Kuhrt, Lutz ; Muller, Klaus ; Schneider, Gisbert ; Schubert-Zsilavecz, Manfred. / Truxillic acid derivatives act as peroxisome proliferator-activated receptor γ activators. In: Bioorganic and Medicinal Chemistry Letters. 2010 ; Vol. 20, No. 9. pp. 2920-2923.
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