Abstract
The upregulation of the initiating step of the kynurenine pathway was demonstrated in postmortem anterior cingulated cortex from individuals with schizophrenia and bipolar disorder. However, the tryptophan and kynurenine metabolism in bipolar mania patients especially in drug naïve state has not been clearly explored. This study explored the plasma tryptophan and its competing amino acids, kynurenine, kynurenic acid and 3-hydroxyanthranillic acid and their association with psychopathological scores in 39 drug naïve and drug-free bipolar manic patients in comparison with 80 healthy controls. When age and gender were controlled in multivariate analysis, bipolar manic patients have significantly lower tryptophan index than normal controls (f = 9.779, p = 0.004). The mean plasma tryptophan concentration and mean tryptophan index were reduced and mean tryptophan breakdown index was increased significantly after a 6-week treatment. The reduction in plasma tryptophan and reduction in tryptophan index showed significant negative correlation with reduction in YMRS score (r = - 0.577, p = 0.019 and r = - 0.520, p = 0.039 respectively). The reduction in YMRS also showed positive correlation with both plasma tryptophan concentration and tryptophan index both at the time of admission (r = 0.464, p = 0.019 and r = 0.4, p = 0.047 respectively) and discharged (r = 0.529, p = 0.035 and r = 0.607, p = 0.013 respectively). The reduction in BPRS score also showed positive correlation with tryptophan index at the time of discharge (r = 0.406, p = 0.044). These findings indicated the involvement of bi-directional tryptophan metabolism and kynurenine pathway in pathophysiology and response to medication in bipolar mania.
| Original language | English |
|---|---|
| Pages (from-to) | 65-72 |
| Number of pages | 8 |
| Journal | Journal of Affective Disorders |
| Volume | 102 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - 2007 Sep 1 |
| Externally published | Yes |
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Keywords
- Bipolar mania
- Kynurenine
- Tryptophan
ASJC Scopus subject areas
- Psychiatry and Mental health
- Behavioral Neuroscience
- Biological Psychiatry
- Neurology
- Psychology(all)
Cite this
Tryptophan breakdown pathway in bipolar mania. / Myint, Aye Mu; Kim, Yong Ku; Verkerk, Robert; Park, Sun-Hwa; Scharpé, Simon; Steinbusch, Harry W M; Leonard, Brian E.
In: Journal of Affective Disorders, Vol. 102, No. 1-3, 01.09.2007, p. 65-72.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tryptophan breakdown pathway in bipolar mania
AU - Myint, Aye Mu
AU - Kim, Yong Ku
AU - Verkerk, Robert
AU - Park, Sun-Hwa
AU - Scharpé, Simon
AU - Steinbusch, Harry W M
AU - Leonard, Brian E.
PY - 2007/9/1
Y1 - 2007/9/1
N2 - The upregulation of the initiating step of the kynurenine pathway was demonstrated in postmortem anterior cingulated cortex from individuals with schizophrenia and bipolar disorder. However, the tryptophan and kynurenine metabolism in bipolar mania patients especially in drug naïve state has not been clearly explored. This study explored the plasma tryptophan and its competing amino acids, kynurenine, kynurenic acid and 3-hydroxyanthranillic acid and their association with psychopathological scores in 39 drug naïve and drug-free bipolar manic patients in comparison with 80 healthy controls. When age and gender were controlled in multivariate analysis, bipolar manic patients have significantly lower tryptophan index than normal controls (f = 9.779, p = 0.004). The mean plasma tryptophan concentration and mean tryptophan index were reduced and mean tryptophan breakdown index was increased significantly after a 6-week treatment. The reduction in plasma tryptophan and reduction in tryptophan index showed significant negative correlation with reduction in YMRS score (r = - 0.577, p = 0.019 and r = - 0.520, p = 0.039 respectively). The reduction in YMRS also showed positive correlation with both plasma tryptophan concentration and tryptophan index both at the time of admission (r = 0.464, p = 0.019 and r = 0.4, p = 0.047 respectively) and discharged (r = 0.529, p = 0.035 and r = 0.607, p = 0.013 respectively). The reduction in BPRS score also showed positive correlation with tryptophan index at the time of discharge (r = 0.406, p = 0.044). These findings indicated the involvement of bi-directional tryptophan metabolism and kynurenine pathway in pathophysiology and response to medication in bipolar mania.
AB - The upregulation of the initiating step of the kynurenine pathway was demonstrated in postmortem anterior cingulated cortex from individuals with schizophrenia and bipolar disorder. However, the tryptophan and kynurenine metabolism in bipolar mania patients especially in drug naïve state has not been clearly explored. This study explored the plasma tryptophan and its competing amino acids, kynurenine, kynurenic acid and 3-hydroxyanthranillic acid and their association with psychopathological scores in 39 drug naïve and drug-free bipolar manic patients in comparison with 80 healthy controls. When age and gender were controlled in multivariate analysis, bipolar manic patients have significantly lower tryptophan index than normal controls (f = 9.779, p = 0.004). The mean plasma tryptophan concentration and mean tryptophan index were reduced and mean tryptophan breakdown index was increased significantly after a 6-week treatment. The reduction in plasma tryptophan and reduction in tryptophan index showed significant negative correlation with reduction in YMRS score (r = - 0.577, p = 0.019 and r = - 0.520, p = 0.039 respectively). The reduction in YMRS also showed positive correlation with both plasma tryptophan concentration and tryptophan index both at the time of admission (r = 0.464, p = 0.019 and r = 0.4, p = 0.047 respectively) and discharged (r = 0.529, p = 0.035 and r = 0.607, p = 0.013 respectively). The reduction in BPRS score also showed positive correlation with tryptophan index at the time of discharge (r = 0.406, p = 0.044). These findings indicated the involvement of bi-directional tryptophan metabolism and kynurenine pathway in pathophysiology and response to medication in bipolar mania.
KW - Bipolar mania
KW - Kynurenine
KW - Tryptophan
UR - http://www.scopus.com/inward/record.url?scp=34447250001&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447250001&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2006.12.008
DO - 10.1016/j.jad.2006.12.008
M3 - Article
C2 - 17270276
AN - SCOPUS:34447250001
VL - 102
SP - 65
EP - 72
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1-3
ER -