Tuberculosis infection and latent tuberculosis

Seung Heon Lee

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)


Active tuberculosis (TB) has a greater burden of TB bacilli than latent TB and acts as an infection source for contacts. Latent tuberculosis infection (LTBI) is the state in which humans are infected with Mycobacterium tuberculosis without any clinical symptoms, radiological abnormality, or microbiological evidence. TB is transmissible by respiratory droplet nucleus of 1-5 μm in diameter, containing 1-10 TB bacilli. TB transmission is affected by the strength of the infectious source, infectiousness of TB bacilli, immunoresistance of the host, environmental stresses, and biosocial factors. Infection controls to reduce TB transmission consist of managerial activities, administrative control, engineering control, environmental control, and personal protective equipment provision. However, diagnosis and treatment for LTBI as a national TB control program is an important strategy on the precondition that active TB is not missed. Therefore, more concrete evidences for LTBI management based on clinical and public perspectives are needed.

Original languageEnglish
Pages (from-to)201-206
Number of pages6
JournalTuberculosis and Respiratory Diseases
Issue number4
Publication statusPublished - 2016 Oct
Externally publishedYes


  • Infection
  • Infection Control
  • Latent Tuberculosis
  • Transmission
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases


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