Tumor blood flow differs between mouse strains: Consequences for vasoresponse to photodynamic therapy

Rickson C. Mesquita, Sung Won Han, Joann Miller, Steven S. Schenkel, Andrew Pole, Tatiana V. Esipova, Sergei A. Vinogradov, Mary E. Putt, Arjun G. Yodh, Theresa M. Busch

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Fluctuations in tumor blood flow are common and attributed to factors such as vasomotion or local vascular structure, yet, because vessel structure and physiology are host-derived, animal strain of tumor propagation may further determine blood flow characteristics. In the present report, baseline and stress-altered tumor hemodynamics as a function of murine strain were studied using radiation-induced fibrosacomas (RIF) grown in C3H or nude mice. Fluctuations in tumor blood flow during one hour of baseline monitoring or during vascular stress induced by photodynamic therapy (PDT) were measured by diffuse correlation spectroscopy. Baseline monitoring revealed fluctuating tumor blood flow highly correlated with heart rate and with similar median periods (i.e., ~9 and 14 min in C3H and nudes, respectively). However, tumor blood flow in C3H animals was more sensitive to physiologic or stress-induced perturbations. Specifically, PDT-induced vascular insults produced greater decreases in blood flow in the tumors of C3H versus nude mice; similarly, during baseline monitoring, fluctuations in blood flow were more regular and more prevalent within the tumors of C3H mice versus nude mice; finally, the vasoconstrictor L-NNA reduced tumor blood flow in C3H mice but did not affect tumor blood flow in nudes. Underlying differences in vascular structure, such as smaller tumor blood vessels in C3H versus nude animals, may contribute to strain-dependent variation in vascular function. These data thus identify clear effects of mouse strain on tumor hemodynamics with consequences to PDT and potentially other vascular-mediated therapies.

Original languageEnglish
Article numbere37322
JournalPloS one
Volume7
Issue number5
DOIs
Publication statusPublished - 2012 May 18
Externally publishedYes

Fingerprint

Photodynamic therapy
Photochemotherapy
blood flow
Tumors
Blood
therapeutics
neoplasms
blood vessels
mice
Blood Vessels
Neoplasms
Inbred C3H Mouse
Nude Mice
Animals
Hemodynamics
hemodynamics
Monitoring
monitoring
Vascular Tissue Neoplasms
vasoconstrictor agents

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Mesquita, R. C., Han, S. W., Miller, J., Schenkel, S. S., Pole, A., Esipova, T. V., ... Busch, T. M. (2012). Tumor blood flow differs between mouse strains: Consequences for vasoresponse to photodynamic therapy. PloS one, 7(5), [e37322]. https://doi.org/10.1371/journal.pone.0037322

Tumor blood flow differs between mouse strains : Consequences for vasoresponse to photodynamic therapy. / Mesquita, Rickson C.; Han, Sung Won; Miller, Joann; Schenkel, Steven S.; Pole, Andrew; Esipova, Tatiana V.; Vinogradov, Sergei A.; Putt, Mary E.; Yodh, Arjun G.; Busch, Theresa M.

In: PloS one, Vol. 7, No. 5, e37322, 18.05.2012.

Research output: Contribution to journalArticle

Mesquita, RC, Han, SW, Miller, J, Schenkel, SS, Pole, A, Esipova, TV, Vinogradov, SA, Putt, ME, Yodh, AG & Busch, TM 2012, 'Tumor blood flow differs between mouse strains: Consequences for vasoresponse to photodynamic therapy', PloS one, vol. 7, no. 5, e37322. https://doi.org/10.1371/journal.pone.0037322
Mesquita, Rickson C. ; Han, Sung Won ; Miller, Joann ; Schenkel, Steven S. ; Pole, Andrew ; Esipova, Tatiana V. ; Vinogradov, Sergei A. ; Putt, Mary E. ; Yodh, Arjun G. ; Busch, Theresa M. / Tumor blood flow differs between mouse strains : Consequences for vasoresponse to photodynamic therapy. In: PloS one. 2012 ; Vol. 7, No. 5.
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