Tumor burden assessed by the maximum standardized uptake value and greatest diameter on FDG-PET predicts prognosis in untreated diffuse large B-cell lymphoma

Xuan Canh Nguyen, Won Woo Lee, Amr Mohamed Amin, Jae Seon Eo, Soo Mee Bang, Jong Seok Lee, Sang Eun Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: It is uncertain whether the tumor burden as assessed using FDG-PET has prognostic significance in newly diagnosed diffuse large B-cell lymphoma (DLBCL). The authors undertook this study to determine whether a parameter that reflects both FDG uptake magnitude and the greatest tumor diameter is a prognostic indicator in DLBCL. Materials and Methods: Forty-two DLBCL patients (age, 57.4±15.5 years; male/female=25/17; stage I/II/III/IV=5/ 17/10/10) who underwent FDG-PET before chemotherapy were enrolled. A lesion with the highest maximum standardized uptake value (MaxSUV) on the PET image was selected, and size-incorporated MaxSUV (SIMaxSUV) of mass was calculated as MaxSUV × greatest diameter (mm) on the transaxial PET image. Median follow-up duration was 20.0 months. Results: Twelve (28.6%=12/42) patients experienced disease progression, and 10 (23.8%=10/42) died during follow-up. Among six variables [Ann Arbor stage, %Ki-67 expression, International Prognostic Index (IPI), MaxSUV, greatest diameter, and SIMaxSUV] investigated, only SIMaxSUV was found to be a single determinant of progression-free and overall survivals by multivariate analyses (p<0.05). Conclusion: These results suggest that SIMaxSUV, a new FDG-PET parameter that incorporates FDG uptake magnitude and the greatest tumor diameter, may be a useful indicator of prognosis in untreated DLBCL.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalNuclear Medicine and Molecular Imaging
Volume44
Issue number1
DOIs
Publication statusPublished - 2010 Apr 1
Externally publishedYes

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Lymphoma, Large B-Cell, Diffuse
Tumor Burden
Survival Analysis
Disease-Free Survival
Disease Progression
Neoplasms
Multivariate Analysis
Drug Therapy

Keywords

  • FDG-PET
  • Greatest diameter
  • Lymphoma
  • Prognosis
  • Size-incorporated maxSUV
  • SUV

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Tumor burden assessed by the maximum standardized uptake value and greatest diameter on FDG-PET predicts prognosis in untreated diffuse large B-cell lymphoma. / Nguyen, Xuan Canh; Lee, Won Woo; Amin, Amr Mohamed; Eo, Jae Seon; Bang, Soo Mee; Lee, Jong Seok; Kim, Sang Eun.

In: Nuclear Medicine and Molecular Imaging, Vol. 44, No. 1, 01.04.2010, p. 39-44.

Research output: Contribution to journalArticle

Nguyen, Xuan Canh ; Lee, Won Woo ; Amin, Amr Mohamed ; Eo, Jae Seon ; Bang, Soo Mee ; Lee, Jong Seok ; Kim, Sang Eun. / Tumor burden assessed by the maximum standardized uptake value and greatest diameter on FDG-PET predicts prognosis in untreated diffuse large B-cell lymphoma. In: Nuclear Medicine and Molecular Imaging. 2010 ; Vol. 44, No. 1. pp. 39-44.
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abstract = "Purpose: It is uncertain whether the tumor burden as assessed using FDG-PET has prognostic significance in newly diagnosed diffuse large B-cell lymphoma (DLBCL). The authors undertook this study to determine whether a parameter that reflects both FDG uptake magnitude and the greatest tumor diameter is a prognostic indicator in DLBCL. Materials and Methods: Forty-two DLBCL patients (age, 57.4±15.5 years; male/female=25/17; stage I/II/III/IV=5/ 17/10/10) who underwent FDG-PET before chemotherapy were enrolled. A lesion with the highest maximum standardized uptake value (MaxSUV) on the PET image was selected, and size-incorporated MaxSUV (SIMaxSUV) of mass was calculated as MaxSUV × greatest diameter (mm) on the transaxial PET image. Median follow-up duration was 20.0 months. Results: Twelve (28.6{\%}=12/42) patients experienced disease progression, and 10 (23.8{\%}=10/42) died during follow-up. Among six variables [Ann Arbor stage, {\%}Ki-67 expression, International Prognostic Index (IPI), MaxSUV, greatest diameter, and SIMaxSUV] investigated, only SIMaxSUV was found to be a single determinant of progression-free and overall survivals by multivariate analyses (p<0.05). Conclusion: These results suggest that SIMaxSUV, a new FDG-PET parameter that incorporates FDG uptake magnitude and the greatest tumor diameter, may be a useful indicator of prognosis in untreated DLBCL.",
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AU - Eo, Jae Seon

AU - Bang, Soo Mee

AU - Lee, Jong Seok

AU - Kim, Sang Eun

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N2 - Purpose: It is uncertain whether the tumor burden as assessed using FDG-PET has prognostic significance in newly diagnosed diffuse large B-cell lymphoma (DLBCL). The authors undertook this study to determine whether a parameter that reflects both FDG uptake magnitude and the greatest tumor diameter is a prognostic indicator in DLBCL. Materials and Methods: Forty-two DLBCL patients (age, 57.4±15.5 years; male/female=25/17; stage I/II/III/IV=5/ 17/10/10) who underwent FDG-PET before chemotherapy were enrolled. A lesion with the highest maximum standardized uptake value (MaxSUV) on the PET image was selected, and size-incorporated MaxSUV (SIMaxSUV) of mass was calculated as MaxSUV × greatest diameter (mm) on the transaxial PET image. Median follow-up duration was 20.0 months. Results: Twelve (28.6%=12/42) patients experienced disease progression, and 10 (23.8%=10/42) died during follow-up. Among six variables [Ann Arbor stage, %Ki-67 expression, International Prognostic Index (IPI), MaxSUV, greatest diameter, and SIMaxSUV] investigated, only SIMaxSUV was found to be a single determinant of progression-free and overall survivals by multivariate analyses (p<0.05). Conclusion: These results suggest that SIMaxSUV, a new FDG-PET parameter that incorporates FDG uptake magnitude and the greatest tumor diameter, may be a useful indicator of prognosis in untreated DLBCL.

AB - Purpose: It is uncertain whether the tumor burden as assessed using FDG-PET has prognostic significance in newly diagnosed diffuse large B-cell lymphoma (DLBCL). The authors undertook this study to determine whether a parameter that reflects both FDG uptake magnitude and the greatest tumor diameter is a prognostic indicator in DLBCL. Materials and Methods: Forty-two DLBCL patients (age, 57.4±15.5 years; male/female=25/17; stage I/II/III/IV=5/ 17/10/10) who underwent FDG-PET before chemotherapy were enrolled. A lesion with the highest maximum standardized uptake value (MaxSUV) on the PET image was selected, and size-incorporated MaxSUV (SIMaxSUV) of mass was calculated as MaxSUV × greatest diameter (mm) on the transaxial PET image. Median follow-up duration was 20.0 months. Results: Twelve (28.6%=12/42) patients experienced disease progression, and 10 (23.8%=10/42) died during follow-up. Among six variables [Ann Arbor stage, %Ki-67 expression, International Prognostic Index (IPI), MaxSUV, greatest diameter, and SIMaxSUV] investigated, only SIMaxSUV was found to be a single determinant of progression-free and overall survivals by multivariate analyses (p<0.05). Conclusion: These results suggest that SIMaxSUV, a new FDG-PET parameter that incorporates FDG uptake magnitude and the greatest tumor diameter, may be a useful indicator of prognosis in untreated DLBCL.

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