Tumor-homing glycol chitosan-based optical/PET dual imaging nanoprobe for cancer diagnosis

Sangmin Lee, Sun Woong Kang, Ju Hee Ryu, Jin Hee Na, Dong Eun Lee, Seung Jin Han, Choong Mo Kang, Yearn Seong Choe, Kyo Chul Lee, James F. Leary, Kuiwon Choi, Kyung Han Lee, Kwangmeyung Kim

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Imaging techniques including computed tomography, magnetic resonance imaging, and positron emission tomography (PET) offer many potential benefits to diagnosis and treatment of cancers. Each method has its own strong and weak points. Therefore, multimodal imaging techniques have been highlighted as an alternative method for overcoming the limitations of each respective imaging method. In this study, we fabricated PET/optical activatable imaging probe based on glycol chitosan nanoparticles (CNPs) for multimodal imaging. To prepare the dual PET/optical probes based on CNPs, both 64Cu radiolabeled DOTA complex and activatable matrix metalloproteinase (MMP)-sensitive peptide were chemically conjugated onto azide-functionalized CNPs via bio-orthogonal click chemistry, which was a reaction between azide group and dibenzyl cyclooctyne. The PET/optical activatable imaging probes were visualized by PET and optical imaging system. Biodistribution of probes and activity of MMP were successfully measured in tumor-bearing mice.

Original languageEnglish
Pages (from-to)601-610
Number of pages10
JournalBioconjugate Chemistry
Volume25
Issue number3
DOIs
Publication statusPublished - 2014 Mar 19
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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    Lee, S., Kang, S. W., Ryu, J. H., Na, J. H., Lee, D. E., Han, S. J., Kang, C. M., Choe, Y. S., Lee, K. C., Leary, J. F., Choi, K., Lee, K. H., & Kim, K. (2014). Tumor-homing glycol chitosan-based optical/PET dual imaging nanoprobe for cancer diagnosis. Bioconjugate Chemistry, 25(3), 601-610. https://doi.org/10.1021/bc500020g