Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

So Jin Lee, Myung Sook Huh, Seung Young Lee, Solki Min, Seulki Lee, Heebeom Koo, Jun Uk Chu, Kyung Eun Lee, Hyesung Jeon, Yongseok Choi, Kuiwon Choi, Youngro Byun, Seo Young Jeong, Kinam Park, Kwang Meyung Kim, Ick Chan Kwon

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.

Original languageEnglish
Pages (from-to)7203-7207
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number29
DOIs
Publication statusPublished - 2012 Jul 16

Fingerprint

Oncology
Glycols
Chitosan
Small Interfering RNA
Tumors
Nanoparticles
Proteins
glycol-chitosan

Keywords

  • Antitumor agents
  • Glycol chitosan
  • Nanoparticles
  • Poly-siRNA
  • SiRNA delivery

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment. / Lee, So Jin; Huh, Myung Sook; Lee, Seung Young; Min, Solki; Lee, Seulki; Koo, Heebeom; Chu, Jun Uk; Lee, Kyung Eun; Jeon, Hyesung; Choi, Yongseok; Choi, Kuiwon; Byun, Youngro; Jeong, Seo Young; Park, Kinam; Kim, Kwang Meyung; Kwon, Ick Chan.

In: Angewandte Chemie - International Edition, Vol. 51, No. 29, 16.07.2012, p. 7203-7207.

Research output: Contribution to journalArticle

Lee, SJ, Huh, MS, Lee, SY, Min, S, Lee, S, Koo, H, Chu, JU, Lee, KE, Jeon, H, Choi, Y, Choi, K, Byun, Y, Jeong, SY, Park, K, Kim, KM & Kwon, IC 2012, 'Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment', Angewandte Chemie - International Edition, vol. 51, no. 29, pp. 7203-7207. https://doi.org/10.1002/anie.201201390
Lee, So Jin ; Huh, Myung Sook ; Lee, Seung Young ; Min, Solki ; Lee, Seulki ; Koo, Heebeom ; Chu, Jun Uk ; Lee, Kyung Eun ; Jeon, Hyesung ; Choi, Yongseok ; Choi, Kuiwon ; Byun, Youngro ; Jeong, Seo Young ; Park, Kinam ; Kim, Kwang Meyung ; Kwon, Ick Chan. / Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment. In: Angewandte Chemie - International Edition. 2012 ; Vol. 51, No. 29. pp. 7203-7207.
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