Tumor necrosis factor-α promoter -308 A/G polymorphism and rheumatoid arthritis susceptibility

A metaanalysis

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77 Citations (Scopus)

Abstract

Objective. Tumor necrosis factor-α (TNF-α) promoter -308 A/G polymorphism has been reported to be associated with rheumatoid arthritis (RA) with inconsistent results. We investigated whether TNF-α -308 A/G polymorphism confers susceptibility to RA. Methods. We conducted a random effect metaanalysis on the association of genotypes A/A (recessive effect), A/A + A/G (dominant effect), A allele, and A/A vs G/G genotypes of the TNF-α -308 polymorphisms with RA overall and within different ethnic populations. Results. Fourteen studies, 10 of Europeans, 3 of Latin Americans, and one Asian, were included in this metaanalysis. An association between RA and the TNF-α -308 A allele was not found in the overall population (OR 1.005, 95% CI 0.715-1.412, p = 0.976). However, stratification by ethnicity indicated that the TNF-α A allele was significantly associated with RA in Latin Americans (OR 2.004, 95% CI 1.158-3.467, p = 0.013). Conversely, there was no association detected for the TNF-α A allele with RA patients from the European samples (OR 0.911, 95% CI 0.684-1.212, p = 0.520). The OR for the A/A + A/G genotype, the A/A genotypes, and the A/A vs G/G genotypes in samples overall and in each ethnic group showed a similar trend to those for the TNF-α A allele. Conclusion. This metaanalysis demonstrates that the TNF-α -308 A/G polymorphism may represent a significant risk factor for RA in Latin Americans, but not in Europeans.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalJournal of Rheumatology
Volume34
Issue number1
Publication statusPublished - 2007 Jan 1

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Rheumatoid Arthritis
Tumor Necrosis Factor-alpha
Alleles
Genotype
Asian Americans
Ethnic Groups
Population

Keywords

  • Metaanalysis
  • Polymorphisms
  • Rheumatoid arthritis
  • Susceptibility
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

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title = "Tumor necrosis factor-α promoter -308 A/G polymorphism and rheumatoid arthritis susceptibility: A metaanalysis",
abstract = "Objective. Tumor necrosis factor-α (TNF-α) promoter -308 A/G polymorphism has been reported to be associated with rheumatoid arthritis (RA) with inconsistent results. We investigated whether TNF-α -308 A/G polymorphism confers susceptibility to RA. Methods. We conducted a random effect metaanalysis on the association of genotypes A/A (recessive effect), A/A + A/G (dominant effect), A allele, and A/A vs G/G genotypes of the TNF-α -308 polymorphisms with RA overall and within different ethnic populations. Results. Fourteen studies, 10 of Europeans, 3 of Latin Americans, and one Asian, were included in this metaanalysis. An association between RA and the TNF-α -308 A allele was not found in the overall population (OR 1.005, 95{\%} CI 0.715-1.412, p = 0.976). However, stratification by ethnicity indicated that the TNF-α A allele was significantly associated with RA in Latin Americans (OR 2.004, 95{\%} CI 1.158-3.467, p = 0.013). Conversely, there was no association detected for the TNF-α A allele with RA patients from the European samples (OR 0.911, 95{\%} CI 0.684-1.212, p = 0.520). The OR for the A/A + A/G genotype, the A/A genotypes, and the A/A vs G/G genotypes in samples overall and in each ethnic group showed a similar trend to those for the TNF-α A allele. Conclusion. This metaanalysis demonstrates that the TNF-α -308 A/G polymorphism may represent a significant risk factor for RA in Latin Americans, but not in Europeans.",
keywords = "Metaanalysis, Polymorphisms, Rheumatoid arthritis, Susceptibility, Tumor necrosis factor-α",
author = "Lee, {Young Ho} and Ji, {Jong Dae} and Song, {Gwan Gyu}",
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T1 - Tumor necrosis factor-α promoter -308 A/G polymorphism and rheumatoid arthritis susceptibility

T2 - A metaanalysis

AU - Lee, Young Ho

AU - Ji, Jong Dae

AU - Song, Gwan Gyu

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Objective. Tumor necrosis factor-α (TNF-α) promoter -308 A/G polymorphism has been reported to be associated with rheumatoid arthritis (RA) with inconsistent results. We investigated whether TNF-α -308 A/G polymorphism confers susceptibility to RA. Methods. We conducted a random effect metaanalysis on the association of genotypes A/A (recessive effect), A/A + A/G (dominant effect), A allele, and A/A vs G/G genotypes of the TNF-α -308 polymorphisms with RA overall and within different ethnic populations. Results. Fourteen studies, 10 of Europeans, 3 of Latin Americans, and one Asian, were included in this metaanalysis. An association between RA and the TNF-α -308 A allele was not found in the overall population (OR 1.005, 95% CI 0.715-1.412, p = 0.976). However, stratification by ethnicity indicated that the TNF-α A allele was significantly associated with RA in Latin Americans (OR 2.004, 95% CI 1.158-3.467, p = 0.013). Conversely, there was no association detected for the TNF-α A allele with RA patients from the European samples (OR 0.911, 95% CI 0.684-1.212, p = 0.520). The OR for the A/A + A/G genotype, the A/A genotypes, and the A/A vs G/G genotypes in samples overall and in each ethnic group showed a similar trend to those for the TNF-α A allele. Conclusion. This metaanalysis demonstrates that the TNF-α -308 A/G polymorphism may represent a significant risk factor for RA in Latin Americans, but not in Europeans.

AB - Objective. Tumor necrosis factor-α (TNF-α) promoter -308 A/G polymorphism has been reported to be associated with rheumatoid arthritis (RA) with inconsistent results. We investigated whether TNF-α -308 A/G polymorphism confers susceptibility to RA. Methods. We conducted a random effect metaanalysis on the association of genotypes A/A (recessive effect), A/A + A/G (dominant effect), A allele, and A/A vs G/G genotypes of the TNF-α -308 polymorphisms with RA overall and within different ethnic populations. Results. Fourteen studies, 10 of Europeans, 3 of Latin Americans, and one Asian, were included in this metaanalysis. An association between RA and the TNF-α -308 A allele was not found in the overall population (OR 1.005, 95% CI 0.715-1.412, p = 0.976). However, stratification by ethnicity indicated that the TNF-α A allele was significantly associated with RA in Latin Americans (OR 2.004, 95% CI 1.158-3.467, p = 0.013). Conversely, there was no association detected for the TNF-α A allele with RA patients from the European samples (OR 0.911, 95% CI 0.684-1.212, p = 0.520). The OR for the A/A + A/G genotype, the A/A genotypes, and the A/A vs G/G genotypes in samples overall and in each ethnic group showed a similar trend to those for the TNF-α A allele. Conclusion. This metaanalysis demonstrates that the TNF-α -308 A/G polymorphism may represent a significant risk factor for RA in Latin Americans, but not in Europeans.

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