Tumor-targeting gold particles for dual computed tomography/optical cancer imaging

In Cheol Sun, Dae Kyung Eun, Heebeom Koo, Chang Yong Ko, Han Sung Kim, Dong Kee Yi, Kuiwon Choi, Ick Chan Kwon, Kwang Meyung Kim, Cheol Hee Ahn

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X-ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes.

Original languageEnglish
Pages (from-to)9348-9351
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number40
DOIs
Publication statusPublished - 2011 Sep 26
Externally publishedYes

Fingerprint

Optical tomography
Matrix Metalloproteinases
Gold
Tumors
Imaging techniques
X ray absorption
Glycols
Chitosan
Peptides
Tomography
Surface treatment
Fluorescence
Nanoparticles
Recovery
Metalloproteases
glycol-chitosan

Keywords

  • computed tomography
  • gold
  • imaging agents
  • nanoparticles

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Sun, I. C., Eun, D. K., Koo, H., Ko, C. Y., Kim, H. S., Yi, D. K., ... Ahn, C. H. (2011). Tumor-targeting gold particles for dual computed tomography/optical cancer imaging. Angewandte Chemie - International Edition, 50(40), 9348-9351. https://doi.org/10.1002/anie.201102892

Tumor-targeting gold particles for dual computed tomography/optical cancer imaging. / Sun, In Cheol; Eun, Dae Kyung; Koo, Heebeom; Ko, Chang Yong; Kim, Han Sung; Yi, Dong Kee; Choi, Kuiwon; Kwon, Ick Chan; Kim, Kwang Meyung; Ahn, Cheol Hee.

In: Angewandte Chemie - International Edition, Vol. 50, No. 40, 26.09.2011, p. 9348-9351.

Research output: Contribution to journalArticle

Sun, IC, Eun, DK, Koo, H, Ko, CY, Kim, HS, Yi, DK, Choi, K, Kwon, IC, Kim, KM & Ahn, CH 2011, 'Tumor-targeting gold particles for dual computed tomography/optical cancer imaging', Angewandte Chemie - International Edition, vol. 50, no. 40, pp. 9348-9351. https://doi.org/10.1002/anie.201102892
Sun, In Cheol ; Eun, Dae Kyung ; Koo, Heebeom ; Ko, Chang Yong ; Kim, Han Sung ; Yi, Dong Kee ; Choi, Kuiwon ; Kwon, Ick Chan ; Kim, Kwang Meyung ; Ahn, Cheol Hee. / Tumor-targeting gold particles for dual computed tomography/optical cancer imaging. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 40. pp. 9348-9351.
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