TY - JOUR
T1 - Tumor-targeting multi-functional nanoparticles for theragnosis
T2 - New paradigm for cancer therapy
AU - Ryu, Ju Hee
AU - Koo, Heebeom
AU - Sun, In Cheol
AU - Yuk, Soon Hong
AU - Choi, Kuiwon
AU - Kim, Kwangmeyung
AU - Kwon, Ick Chan
N1 - Funding Information:
This work is supported by the M.D.-Ph.D. Program ( 2010-0019863 , 2010-0019864 ), the Global Research Laboratory Project of MEST , and the Intramural Research Program (Theragnosis) of KIST .
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/10
Y1 - 2012/10
N2 - Theragnostic nanoparticles (NPs) contain diagnostic and therapeutic functions in one integrated system, enabling diagnosis, therapy, and monitoring of therapeutic response at the same time. For diagnostic function, theragnostic NPs require the inclusion of noninvasive imaging modalities. Among them, optical imaging has various advantages including sensitivity, real-time and convenient use, and non-ionization safety, which make it the leading technique for theragnostic NPs. For therapeutic function, theragnostic NPs have been applied to chemotherapy, photodynamic therapy, siRNA therapy and photothermal therapy. In this review, we present a recent progress reported in the development and applications of theragnostic NPs for cancer therapy. More specifically, we will focus on theragnostic NPs related with optical imaging, highlighting promising strategies based on optical imaging techniques.
AB - Theragnostic nanoparticles (NPs) contain diagnostic and therapeutic functions in one integrated system, enabling diagnosis, therapy, and monitoring of therapeutic response at the same time. For diagnostic function, theragnostic NPs require the inclusion of noninvasive imaging modalities. Among them, optical imaging has various advantages including sensitivity, real-time and convenient use, and non-ionization safety, which make it the leading technique for theragnostic NPs. For therapeutic function, theragnostic NPs have been applied to chemotherapy, photodynamic therapy, siRNA therapy and photothermal therapy. In this review, we present a recent progress reported in the development and applications of theragnostic NPs for cancer therapy. More specifically, we will focus on theragnostic NPs related with optical imaging, highlighting promising strategies based on optical imaging techniques.
KW - Cancer
KW - Chemotherapy
KW - Molecular imaging
KW - Nanomedicine
KW - Optical imaging
KW - Personalized medicine
KW - Photodynamic therapy
KW - Photothermal therapy
KW - SiRNA therapy
KW - Theragnosis
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U2 - 10.1016/j.addr.2012.06.012
DO - 10.1016/j.addr.2012.06.012
M3 - Review article
C2 - 22772034
AN - SCOPUS:84867643331
SN - 0169-409X
VL - 64
SP - 1447
EP - 1458
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
IS - 13
ER -
