Tumor-targeting multifunctional nanoparticles for sirna delivery: Recent advances in cancer therapy

Sook Hee Ku, Kwang Meyung Kim, Kuiwon Choi, Sun Hwa Kim, Ick Chan Kwon

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

RNA interference (RNAi) is a naturally occurring regulatory process that controls posttranscriptional gene expression. Small interfering RNA (siRNA), a common form of RNAi-based therapeutics, offers new opportunities for cancer therapy via silencing specific genes, which are associated to cancer progress. However, clinical applications of RNAi-based therapy are still limited due to the easy degradation of siRNA during body circulation and the difficulty in the delivery of siRNA to desired tissues and cells. Thus, there have been many efforts to develop efficient siRNA delivery systems, which protect siRNA from serum nucleases and deliver siRNA to the intracellular region of target cells. Here, the recent advances in siRNA nanocarriers, which possess tumor-targeting ability are reviewed; various nanoparticle systems and their antitumor effects are summarized. The development of multifunctional nanocarriers for theranostics or combinatorial therapy is also discussed.

Original languageEnglish
Pages (from-to)1182-1193
Number of pages12
JournalAdvanced healthcare materials
Volume3
Issue number8
DOIs
Publication statusPublished - 2014 Jan 1

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Pharmaceutical Science

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