Tumor treating fields (TTF) treatment enhances radiation-induced apoptosis in pancreatic cancer cells

Yunhui Jo, Geon Oh, Yongha Gi, Heehun Sung, Eun Bin Joo, Suk Lee, Myonggeun Yoon

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Purpose: Tumor treating fields (TTF) therapy is a noninvasive method that uses alternating electric fields to treat various types of cancer. This study demonstrates the combined effect of TTF and radiotherapy (RT) in vitro on pancreatic cancer, which is known to be difficult to treat. Materials and methods: In CFPAC-I and HPAF-II pancreatic cancer cell lines, the combined in vitro effect of TTF and RT was evaluated by measuring cell counts, markers of apoptosis, and clonogenic cell survival. The synergy effects were verified using the Valeriote and Carpentier equations. Results: TTF and RT inhibited cancer cell growth more effectively than did monotherapy with TTF or RT. The combined treatment also enhanced apoptosis more than monotherapy, as shown by assays for cleaved poly (ADP-ribose) polymerase (PARP) and annexin V. In addition, on the survival curve, this treatment method has been shown to work synergistically. Conclusion: These results suggest that combined treatment with TTF and RT may be a good alternative treatment for patients with pancreatic cancer.

Original languageEnglish
Pages (from-to)1528-1533
Number of pages6
JournalInternational Journal of Radiation Biology
Volume96
Issue number12
DOIs
Publication statusPublished - 2020

Keywords

  • Tumor treating fields
  • cancer therapy
  • combined therapy
  • pancreatic cancer
  • radiotherapy

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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