Tuning and maximizing the single-molecule surface-enhanced Raman scattering from DNA-tethered nanodumbbells

Jung Hoon Lee, Jwa Min Nam, Ki Seok Jeon, Dong-Kwon Lim, Hyoki Kim, Sunghoon Kwon, Haemi Lee, Yung Doug Suh

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

We extensively study the relationships between single-molecule surface-enhanced Raman scattering (SMSERS) intensity, enhancement factor (EF) distribution over many particles, interparticle distance, particle size/shape/composition and excitation laser wavelength using the single-particle AFM-correlated Raman measurement method and theoretical calculations. Two different single-DNA-tethered Au-Ag core-shell nanodumbbell (GSND) designs with an engineerable nanogap were used in this study: the GSND-I with various interparticle nanogaps from ∼4.8 nm to <1 nm or with no gap and the GSND-II with the fixed interparticle gap size and varying particle size from a 23-30 nm pair to a 50-60 nm pair. From the GSND-I, we learned that synthesizing a <1 nm gap is a key to obtain strong SMSERS signals with a narrow EF value distribution. Importantly, in the case of the GSND-I with <1 nm interparticle gap, an EF value of as high as 5.9 ×1013 (average value = 1.8 ×1013) was obtained and the EF values of analyzed particles were narrowly distributed between 1.9 ×1012 and 5.9 ×1013. In the case of the GSND-II probes, a combination of >50 nm Au cores and 514.5 nm laser wavelength that matches well with Ag shell generated stronger SMSERS signals with a more narrow EF distribution than <50 nm Au cores with 514.5 nm laser or the GSND-II structures with 632.8 nm laser. Our results show the usefulness and flexibility of these GSND structures in studying and obtaining SMSERS structures with a narrow distribution of high EF values and that the GSNDs with < 1 nm are promising SERS probes with highly sensitive and quantitative detection capability when optimally designed.

Original languageEnglish
Pages (from-to)9574-9584
Number of pages11
JournalACS Nano
Volume6
Issue number11
DOIs
Publication statusPublished - 2012 Nov 27
Externally publishedYes

Fingerprint

Raman scattering
DNA
deoxyribonucleic acid
Tuning
tuning
Raman spectra
Molecules
Lasers
lasers
augmentation
molecules
Wavelength
Laser excitation
Particle size
wavelengths
flexibility
atomic force microscopy
Chemical analysis
probes
excitation

Keywords

  • core shell particle
  • enhancement factor
  • nanogap
  • plasmonic probe
  • single-molecule detection
  • surface-enhanced Raman scattering

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Tuning and maximizing the single-molecule surface-enhanced Raman scattering from DNA-tethered nanodumbbells. / Lee, Jung Hoon; Nam, Jwa Min; Jeon, Ki Seok; Lim, Dong-Kwon; Kim, Hyoki; Kwon, Sunghoon; Lee, Haemi; Suh, Yung Doug.

In: ACS Nano, Vol. 6, No. 11, 27.11.2012, p. 9574-9584.

Research output: Contribution to journalArticle

Lee, Jung Hoon ; Nam, Jwa Min ; Jeon, Ki Seok ; Lim, Dong-Kwon ; Kim, Hyoki ; Kwon, Sunghoon ; Lee, Haemi ; Suh, Yung Doug. / Tuning and maximizing the single-molecule surface-enhanced Raman scattering from DNA-tethered nanodumbbells. In: ACS Nano. 2012 ; Vol. 6, No. 11. pp. 9574-9584.
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