Tuning polymeric and drug properties in a drug eluting stent

A numerical study

Jahed Naghipoor, José A. Ferreira, Paula de Oliveira, Timon Rabczuk

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A two dimensional coupled nonlinear non-Fickian model for drug release from a biodegradable drug eluting stent into the arterial wall is studied. The influence of porosity and degradation of the polymer as well as the dissolution rate of the drug are analyzed. Numerical simulations that illustrate the kind of dependence of drug profiles on these properties are included.

Original languageEnglish
JournalApplied Mathematical Modelling
DOIs
Publication statusAccepted/In press - 2015 Aug 14
Externally publishedYes

Fingerprint

Stent
Stents
Numerical Study
Tuning
Drugs
Dissolution
Porosity
Degradation
Computer simulation
Polymers
Numerical Simulation

Keywords

  • Dissolved drug
  • Domain decomposition methods
  • Drug eluting stent
  • Numerical simulation

ASJC Scopus subject areas

  • Applied Mathematics
  • Modelling and Simulation

Cite this

Tuning polymeric and drug properties in a drug eluting stent : A numerical study. / Naghipoor, Jahed; Ferreira, José A.; Oliveira, Paula de; Rabczuk, Timon.

In: Applied Mathematical Modelling, 14.08.2015.

Research output: Contribution to journalArticle

Naghipoor, Jahed ; Ferreira, José A. ; Oliveira, Paula de ; Rabczuk, Timon. / Tuning polymeric and drug properties in a drug eluting stent : A numerical study. In: Applied Mathematical Modelling. 2015.
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