Tuning polymeric and drug properties in a drug eluting stent: A numerical study

Jahed Naghipoor, José A. Ferreira, Paula de Oliveira, Timon Rabczuk

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A two dimensional coupled nonlinear non-Fickian model for drug release from a biodegradable drug eluting stent into the arterial wall is studied. The influence of porosity and degradation of the polymer as well as the dissolution rate of the drug are analyzed. Numerical simulations that illustrate the kind of dependence of drug profiles on these properties are included.

Original languageEnglish
Pages (from-to)8067-8086
Number of pages20
JournalApplied Mathematical Modelling
Volume40
Issue number17-18
DOIs
Publication statusPublished - 2016 Sep 1

Keywords

  • Dissolved drug
  • Domain decomposition methods
  • Drug eluting stent
  • Numerical simulation

ASJC Scopus subject areas

  • Modelling and Simulation
  • Applied Mathematics

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