Two different renal cell carcinomas and multiple angiomyolipomas in a patient with tuberous sclerosis

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Abstract

We report a case of tuberous sclerosis associated with two histologically different renal cell carcinomas (RCCs) and multiple angiomyolipomas (AMLs) in the same kidney. A 43-year-old female was admitted to our hospital with left flank pain and a huge palpable mass in the left flank area. Abdominal computed tomography revealed two concurrent RCCs and multiple AMLs in the left kidney. Because of the clinical suspicion of RCC, the patient underwent left radical nephrectomy. On gross examination, the total size of the resected left kidney was 30.5x17x8 cm. Microscopically, the upper pole tumor features were consistent with chromophobe RCC and the midpole tumor was a clear-cell RCC. The multifocal masses in the remaining remnant parenchyma were AMLs. Six months after surgery, the patient is healthy without signs of tumor recurrence.

Original languageEnglish
Pages (from-to)729-732
Number of pages4
JournalKorean Journal of Urology
Volume51
Issue number10
DOIs
Publication statusPublished - 2010 Oct 1

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Angiomyolipoma
Tuberous Sclerosis
Renal Cell Carcinoma
Kidney
Flank Pain
Neoplasms
Nephrectomy
Tomography
Recurrence

Keywords

  • Angiomyolipoma
  • Clear cell renal carcinoma
  • Renal cell carcinoma
  • Tuberous sclerosis

ASJC Scopus subject areas

  • Urology

Cite this

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title = "Two different renal cell carcinomas and multiple angiomyolipomas in a patient with tuberous sclerosis",
abstract = "We report a case of tuberous sclerosis associated with two histologically different renal cell carcinomas (RCCs) and multiple angiomyolipomas (AMLs) in the same kidney. A 43-year-old female was admitted to our hospital with left flank pain and a huge palpable mass in the left flank area. Abdominal computed tomography revealed two concurrent RCCs and multiple AMLs in the left kidney. Because of the clinical suspicion of RCC, the patient underwent left radical nephrectomy. On gross examination, the total size of the resected left kidney was 30.5x17x8 cm. Microscopically, the upper pole tumor features were consistent with chromophobe RCC and the midpole tumor was a clear-cell RCC. The multifocal masses in the remaining remnant parenchyma were AMLs. Six months after surgery, the patient is healthy without signs of tumor recurrence.",
keywords = "Angiomyolipoma, Clear cell renal carcinoma, Renal cell carcinoma, Tuberous sclerosis",
author = "Sung-Gu Kang and Ko, {Young Hwii} and Kang, {Seok Ho} and Jin Kim and Kim, {Chul Hwan} and Park, {Hong Seok} and Moon, {Du Geon} and Lee, {Jeong Gu} and Je-Jong Kim and Jun Cheon",
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T1 - Two different renal cell carcinomas and multiple angiomyolipomas in a patient with tuberous sclerosis

AU - Kang, Sung-Gu

AU - Ko, Young Hwii

AU - Kang, Seok Ho

AU - Kim, Jin

AU - Kim, Chul Hwan

AU - Park, Hong Seok

AU - Moon, Du Geon

AU - Lee, Jeong Gu

AU - Kim, Je-Jong

AU - Cheon, Jun

PY - 2010/10/1

Y1 - 2010/10/1

N2 - We report a case of tuberous sclerosis associated with two histologically different renal cell carcinomas (RCCs) and multiple angiomyolipomas (AMLs) in the same kidney. A 43-year-old female was admitted to our hospital with left flank pain and a huge palpable mass in the left flank area. Abdominal computed tomography revealed two concurrent RCCs and multiple AMLs in the left kidney. Because of the clinical suspicion of RCC, the patient underwent left radical nephrectomy. On gross examination, the total size of the resected left kidney was 30.5x17x8 cm. Microscopically, the upper pole tumor features were consistent with chromophobe RCC and the midpole tumor was a clear-cell RCC. The multifocal masses in the remaining remnant parenchyma were AMLs. Six months after surgery, the patient is healthy without signs of tumor recurrence.

AB - We report a case of tuberous sclerosis associated with two histologically different renal cell carcinomas (RCCs) and multiple angiomyolipomas (AMLs) in the same kidney. A 43-year-old female was admitted to our hospital with left flank pain and a huge palpable mass in the left flank area. Abdominal computed tomography revealed two concurrent RCCs and multiple AMLs in the left kidney. Because of the clinical suspicion of RCC, the patient underwent left radical nephrectomy. On gross examination, the total size of the resected left kidney was 30.5x17x8 cm. Microscopically, the upper pole tumor features were consistent with chromophobe RCC and the midpole tumor was a clear-cell RCC. The multifocal masses in the remaining remnant parenchyma were AMLs. Six months after surgery, the patient is healthy without signs of tumor recurrence.

KW - Angiomyolipoma

KW - Clear cell renal carcinoma

KW - Renal cell carcinoma

KW - Tuberous sclerosis

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