Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures

Pierre Waffo-Teguo, Dongho Lee, Muriel Cuendet, Jean Michel Mërillon, John M. Pezzuto, A. Douglas Kinghorn

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Two new stilbene dimer glucosides, resveratrol (E)-dehydrodimer 11-O-β-D-glucopyranoside (1) and resveratrol (E)-dehydrodimer 11′-O-β-D-glucopyranoside (2), were isolated together with the known resveratrol (E)-dehydrodimer (3) and pallidol (4) from Vitis vinifera cell cultures. The structures and stereochemistry of the new compounds were determined on the basis of spectroscopic data analysis. Compounds 1 and 2 are dimers that belong to a new type of oligostilbene formed from a resveratrol unit and a resveratrol glucoside unit. Compounds 1 and 3 exhibited nonspecific inhibitory activity against cyclooxygenase-1 and -2, with IC50 values in the range of 5 μM, whereas compound 4 was approximately 10-fold less active.

Original languageEnglish
Pages (from-to)136-138
Number of pages3
JournalJournal of Natural Products
Volume64
Issue number1
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Waffo-Teguo, P., Lee, D., Cuendet, M., Mërillon, J. M., Pezzuto, J. M., & Douglas Kinghorn, A. (2001). Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures. Journal of Natural Products, 64(1), 136-138. https://doi.org/10.1021/np000426r