Abstract
Two new stilbene dimer glucosides, resveratrol (E)-dehydrodimer 11-O-β-D-glucopyranoside (1) and resveratrol (E)-dehydrodimer 11′-O-β-D-glucopyranoside (2), were isolated together with the known resveratrol (E)-dehydrodimer (3) and pallidol (4) from Vitis vinifera cell cultures. The structures and stereochemistry of the new compounds were determined on the basis of spectroscopic data analysis. Compounds 1 and 2 are dimers that belong to a new type of oligostilbene formed from a resveratrol unit and a resveratrol glucoside unit. Compounds 1 and 3 exhibited nonspecific inhibitory activity against cyclooxygenase-1 and -2, with IC50 values in the range of 5 μM, whereas compound 4 was approximately 10-fold less active.
| Original language | English |
|---|---|
| Pages (from-to) | 136-138 |
| Number of pages | 3 |
| Journal | Journal of Natural Products |
| Volume | 64 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2001 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Cite this
Waffo-Teguo, P., Lee, D., Cuendet, M., Mërillon, J. M., Pezzuto, J. M., & Douglas Kinghorn, A. (2001). Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures. Journal of Natural Products, 64(1), 136-138. https://doi.org/10.1021/np000426r