Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures

Pierre Waffo-Teguo, Dongho Lee, Muriel Cuendet, Jean Michel Mërillon, John M. Pezzuto, A. Douglas Kinghorn

Research output: Contribution to journalArticlepeer-review

97 Citations (Scopus)


Two new stilbene dimer glucosides, resveratrol (E)-dehydrodimer 11-O-β-D-glucopyranoside (1) and resveratrol (E)-dehydrodimer 11′-O-β-D-glucopyranoside (2), were isolated together with the known resveratrol (E)-dehydrodimer (3) and pallidol (4) from Vitis vinifera cell cultures. The structures and stereochemistry of the new compounds were determined on the basis of spectroscopic data analysis. Compounds 1 and 2 are dimers that belong to a new type of oligostilbene formed from a resveratrol unit and a resveratrol glucoside unit. Compounds 1 and 3 exhibited nonspecific inhibitory activity against cyclooxygenase-1 and -2, with IC50 values in the range of 5 μM, whereas compound 4 was approximately 10-fold less active.

Original languageEnglish
Pages (from-to)136-138
Number of pages3
JournalJournal of Natural Products
Issue number1
Publication statusPublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


Dive into the research topics of 'Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures'. Together they form a unique fingerprint.

Cite this