Two-photon fluorescent turn-on probe for lipid rafts in live cell and tissue

Myung Kim Hwan; Ha Jeong Byeong; Ju Yong Hyon; Jin An Myoung; Sik Seo Mun; Hee Hong Jin; Kyoung Jin Lee; Hoon Kim Chul; Taiha Joo; Seok Cheol Hong; Bong-Rae Cho

doi:10.1021/ja711391f

Two-photon fluorescent turn-on probe for lipid rafts in live cell and tissue

Myung Kim Hwan, Ha Jeong Byeong, Ju Yong Hyon, Jin An Myoung, Sik Seo Mun, Hee Hong Jin, Kyoung Jin Lee, Hoon Kim Chul, Taiha Joo, Seok Cheol Hong, Bong-Rae Cho

Research output: Contribution to journal › Article

106 Citations (Scopus)

Abstract

We report a new two-photon fluorescence turn-on probe 6-[(E)-3-oxo-1-dodecenyl]-2-[N-methyl-N-(carboxymethyl)amino]naphthalene (CL2) that is designed specifically for visualizing lipid rafts in living cells and tissues. This probe emits much brighter two-photon excited fluorescence in lipid rafts than in non-raft domains and allows direct visualization of the lipid rafts in the live cells and pyramidal neuron layer of the CA1 region at a depth of 100-250 μm in live tissues using two-photon microscopy.

Original language	English
Pages (from-to)	4246-4247
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	130
Issue number	13
DOIs	https://doi.org/10.1021/ja711391f
Publication status	Published - 2008 Apr 2

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ASJC Scopus subject areas

Chemistry(all)

Cite this

Hwan, M. K., Byeong, H. J., Hyon, J. Y., Myoung, J. A., Mun, S. S., Jin, H. H., Lee, K. J., Chul, H. K., Joo, T., Hong, S. C., & Cho, B-R. (2008). Two-photon fluorescent turn-on probe for lipid rafts in live cell and tissue. Journal of the American Chemical Society, 130(13), 4246-4247. https://doi.org/10.1021/ja711391f

Two-photon fluorescent turn-on probe for lipid rafts in live cell and tissue. / Hwan, Myung Kim; Byeong, Ha Jeong; Hyon, Ju Yong; Myoung, Jin An; Mun, Sik Seo; Jin, Hee Hong; Lee, Kyoung Jin; Chul, Hoon Kim; Joo, Taiha; Hong, Seok Cheol ; Cho, Bong-Rae.

In: Journal of the American Chemical Society, Vol. 130, No. 13, 02.04.2008, p. 4246-4247.

Research output: Contribution to journal › Article

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10.1021/ja711391f