Abstract
We report a new two-photon fluorescence turn-on probe 6-[(E)-3-oxo-1-dodecenyl]-2-[N-methyl-N-(carboxymethyl)amino]naphthalene (CL2) that is designed specifically for visualizing lipid rafts in living cells and tissues. This probe emits much brighter two-photon excited fluorescence in lipid rafts than in non-raft domains and allows direct visualization of the lipid rafts in the live cells and pyramidal neuron layer of the CA1 region at a depth of 100-250 μm in live tissues using two-photon microscopy.
| Original language | English |
|---|---|
| Pages (from-to) | 4246-4247 |
| Number of pages | 2 |
| Journal | Journal of the American Chemical Society |
| Volume | 130 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - 2008 Apr 2 |
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ASJC Scopus subject areas
- Chemistry(all)
Cite this
Two-photon fluorescent turn-on probe for lipid rafts in live cell and tissue. / Hwan, Myung Kim; Byeong, Ha Jeong; Hyon, Ju Yong; Myoung, Jin An; Mun, Sik Seo; Jin, Hee Hong; Lee, Kyoung Jin; Chul, Hoon Kim; Joo, Taiha; Hong, Seok Cheol; Cho, Bong-Rae.
In: Journal of the American Chemical Society, Vol. 130, No. 13, 02.04.2008, p. 4246-4247.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Two-photon fluorescent turn-on probe for lipid rafts in live cell and tissue
AU - Hwan, Myung Kim
AU - Byeong, Ha Jeong
AU - Hyon, Ju Yong
AU - Myoung, Jin An
AU - Mun, Sik Seo
AU - Jin, Hee Hong
AU - Lee, Kyoung Jin
AU - Chul, Hoon Kim
AU - Joo, Taiha
AU - Hong, Seok Cheol
AU - Cho, Bong-Rae
PY - 2008/4/2
Y1 - 2008/4/2
N2 - We report a new two-photon fluorescence turn-on probe 6-[(E)-3-oxo-1-dodecenyl]-2-[N-methyl-N-(carboxymethyl)amino]naphthalene (CL2) that is designed specifically for visualizing lipid rafts in living cells and tissues. This probe emits much brighter two-photon excited fluorescence in lipid rafts than in non-raft domains and allows direct visualization of the lipid rafts in the live cells and pyramidal neuron layer of the CA1 region at a depth of 100-250 μm in live tissues using two-photon microscopy.
AB - We report a new two-photon fluorescence turn-on probe 6-[(E)-3-oxo-1-dodecenyl]-2-[N-methyl-N-(carboxymethyl)amino]naphthalene (CL2) that is designed specifically for visualizing lipid rafts in living cells and tissues. This probe emits much brighter two-photon excited fluorescence in lipid rafts than in non-raft domains and allows direct visualization of the lipid rafts in the live cells and pyramidal neuron layer of the CA1 region at a depth of 100-250 μm in live tissues using two-photon microscopy.
UR - http://www.scopus.com/inward/record.url?scp=41549154247&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41549154247&partnerID=8YFLogxK
U2 - 10.1021/ja711391f
DO - 10.1021/ja711391f
M3 - Article
C2 - 18331041
AN - SCOPUS:41549154247
VL - 130
SP - 4246
EP - 4247
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 13
ER -