Two-Photon Probes for Lysosomes and Mitochondria: Simultaneous Detection of Lysosomes and Mitochondria in Live Tissues by Dual-Color Two-Photon Microscopy Imaging

Chang Su Lim, Seung Taek Hong, Seong Shick Ryu, Dong Eun Kang, Bong-Rae Cho

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Novel two-photon (TP) probes were developed for lysosomes (PLT-yellow) and mitochondria (BMT-blue and PMT-yellow). These probes emitted strong TP-excited fluorescence in cells at widely separated wavelength regions and displayed high organelle selectivity, good cell permeability, low cytotoxicity, and pH insensitivity. The BMT-blue and PLT-yellow probes could be utilized to detect lysosomes and mitochondria simultaneously in live tissues by using dual-color two-photon microscopy, with minimum interference from each other.

Original languageEnglish
Pages (from-to)2240-2249
Number of pages10
JournalChemistry - An Asian Journal
Volume10
Issue number10
DOIs
Publication statusPublished - 2015 Oct 1

Keywords

  • fluorescent probes
  • imaging agents
  • lysosomes
  • mitochondria
  • two photon

ASJC Scopus subject areas

  • Chemistry(all)

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