Two-pore domain potassium channels in astrocytes

Kanghyun Ryoo, Jae-Yong Park

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Two-pore domain potassium (K 2P ) channels have a distinct structure and channel properties, and are involved in a background K + current. The 15 members of the K 2P channels are identified and classified into six subfamilies on the basis of their sequence similarities. The activity of the channels is dynamically regulated by various physical, chemical, and biological effectors. The channels are expressed in a wide variety of tissues in mammals in an isoform specific manner, and play various roles in many physiological and pathophysiological conditions. To function as channels, the K 2P channels form dimers, and some isoforms form heterodimers that provide diversity in channel properties. In the brain, TWIK1, TREK1, TREK2, TRAAK, TASK1, and TASK3 are predominantly expressed in various regions, including the cerebral cortex, dentate gyrus, CA1-CA3, and granular layer of the cerebellum. TWIK1, TREK1, and TASK1 are highly expressed in astrocytes, where they play specific cellular roles. Astrocytes keep leak K + conductance, called the passive conductance, which mainly involves TWIK1-TREK1 heterodimeric channel. TWIK1 and TREK1 also mediate glutamate release from astrocytes in an exocytosis-independent manner. The expression of TREK1 and TREK2 in astrocytes increases under ischemic conditions, that enhance neuroprotection from ischemia. Accumulated evidence has indicated that astrocytes, together with neurons, are involved in brain function, with the K2P channels playing critical role in these astrocytes.

Original languageEnglish
Pages (from-to)222-232
Number of pages11
JournalExperimental Neurobiology
Volume25
Issue number5
DOIs
Publication statusPublished - 2016 Oct 1

Keywords

  • Astrocyte
  • Glutamate release
  • K channel
  • Passive conductance

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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