Objective: The aim of this study was to investigate whether the thymidylate synthase (TYMS) 2R/3R and 6?bp I/D polymorphisms can predict the response to or toxicity of methotrexate (MTX) in patients with rheumatoid arthritis (RA). Methods: We conducted a meta-analysis of studies on the association between the TYMS 2R/3R and 6?bp I/D polymorphisms and non-responsiveness to or toxicity of MTX in RA patients. Results: A total of 11 studies involving 1613 patients were considered. Meta-analysis showed no association between the TYMS 2R/3R 3R allele and non-responsiveness to MTX therapy (odds ratio [OR]?= 1.087, confidence interval [CI]?= 0.682–1.731, p?= 0.726). The meta-analysis indicated that there was no association between the TYMS 6?bp I/D D allele and non-responsiveness to MTX therapy (OR?= 0.688, 95% CI?= 0.281–1.683, p?= 0.413). Meta-analysis revealed that the TYMS 2R/3R polymorphism was not associated with MTX toxicity, except for in a co-dominant model, and the TYMS 6?bp I/D polymorphism was not associated with MTX toxicity in all genetic models. Conclusions: This meta-analysis demonstrates that the TYMS 2R/3R and 6?bp I/D polymorphisms may not be associated with non-responsiveness to or toxicity of MTX therapy in RA patients.
|Translated title of the contribution||TYMS polymorphisms and responsiveness to or toxicity of methotrexate in rheumatoid arthritis|
|Number of pages||8|
|Journal||Zeitschrift fur Rheumatologie|
|Publication status||Accepted/In press - 2018 Jan 29|
- Rheumatoid arthritis
- TYMS polymorphism
ASJC Scopus subject areas