TYMS-Polymorphismen und Empfindlichkeit gegenüber oder Toxizität von Methotrexat bei rheumatoider Arthritis

Translated title of the contribution: TYMS polymorphisms and responsiveness to or toxicity of methotrexate in rheumatoid arthritis

Sang Cheol Bae, Young Ho Lee

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    Objective: The aim of this study was to investigate whether the thymidylate synthase (TYMS) 2R/3R and 6 bp I/D polymorphisms can predict the response to or toxicity of methotrexate (MTX) in patients with rheumatoid arthritis (RA). Methods: We conducted a meta-analysis of studies on the association between the TYMS 2R/3R and 6 bp I/D polymorphisms and non-responsiveness to or toxicity of MTX in RA patients. Results: A total of 11 studies involving 1613 patients were considered. Meta-analysis showed no association between the TYMS 2R/3R 3R allele and non-responsiveness to MTX therapy (odds ratio [OR] = 1.087, confidence interval [CI] = 0.682–1.731, p = 0.726). The meta-analysis indicated that there was no association between the TYMS 6 bp I/D D allele and non-responsiveness to MTX therapy (OR = 0.688, 95% CI = 0.281–1.683, p = 0.413). Meta-analysis revealed that the TYMS 2R/3R polymorphism was not associated with MTX toxicity, except for in a co-dominant model, and the TYMS 6 bp I/D polymorphism was not associated with MTX toxicity in all genetic models. Conclusions: This meta-analysis demonstrates that the TYMS 2R/3R and 6 bp I/D polymorphisms may not be associated with non-responsiveness to or toxicity of MTX therapy in RA patients.

    Translated title of the contributionTYMS polymorphisms and responsiveness to or toxicity of methotrexate in rheumatoid arthritis
    Original languageGerman
    Pages (from-to)824-832
    Number of pages9
    JournalZeitschrift fur Rheumatologie
    Volume77
    Issue number9
    DOIs
    Publication statusPublished - 2018 Nov 1

    Keywords

    • Methotrexate
    • Rheumatoid arthritis
    • TYMS polymorphism

    ASJC Scopus subject areas

    • Rheumatology

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