Type I calmodulin-sensitive adenylyl cyclase is neural specific

Zhengui Xia, Eui Ju Choi, Fan Wang, Christine Blazynski, Daniel R. Storm

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

The distribution of type I calmodulin-sensitive adenylyl cyclase in bovine and rat tissues was examined by northern blot analysis and in situ hybridization. Northern blot analysis using poly(A)+-selected RNA from various bovine tissues indicated that mRNA for type I adenylyl cyclase was found only in brain, retina, and adrenal medulla, suggesting that this enzyme is neural specific. In situ hybridization studies using bovine, rabbit, and rat retina indicated that mRNA for type I adenylyl cyclase is found in all three nuclear layers of the neural retina and is particularly abundant in the inner segment of the photoreceptor cells. The neural-specific distribution of type I adenylyl cyclase mRNA and its restricted expression in areas of brain implicated in neuroplasticity are consistent with the proposal that this enzyme plays an important role in various neuronal functions including learning and memory.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalJournal of Neurochemistry
Volume60
Issue number1
Publication statusPublished - 1993 Jan 1
Externally publishedYes

Fingerprint

Calmodulin
Adenylyl Cyclases
Retina
Messenger RNA
Rats
Brain
Northern Blotting
Tissue
In Situ Hybridization
Enzymes
Photoreceptor Cells
Neuronal Plasticity
Adrenal Medulla
Data storage equipment
Learning
Rabbits
adenylyl cyclase 1

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Xia, Z., Choi, E. J., Wang, F., Blazynski, C., & Storm, D. R. (1993). Type I calmodulin-sensitive adenylyl cyclase is neural specific. Journal of Neurochemistry, 60(1), 305-311.

Type I calmodulin-sensitive adenylyl cyclase is neural specific. / Xia, Zhengui; Choi, Eui Ju; Wang, Fan; Blazynski, Christine; Storm, Daniel R.

In: Journal of Neurochemistry, Vol. 60, No. 1, 01.01.1993, p. 305-311.

Research output: Contribution to journalArticle

Xia, Z, Choi, EJ, Wang, F, Blazynski, C & Storm, DR 1993, 'Type I calmodulin-sensitive adenylyl cyclase is neural specific', Journal of Neurochemistry, vol. 60, no. 1, pp. 305-311.
Xia Z, Choi EJ, Wang F, Blazynski C, Storm DR. Type I calmodulin-sensitive adenylyl cyclase is neural specific. Journal of Neurochemistry. 1993 Jan 1;60(1):305-311.
Xia, Zhengui ; Choi, Eui Ju ; Wang, Fan ; Blazynski, Christine ; Storm, Daniel R. / Type I calmodulin-sensitive adenylyl cyclase is neural specific. In: Journal of Neurochemistry. 1993 ; Vol. 60, No. 1. pp. 305-311.
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