Abstract
The type III secretion system (T3SS) in Pseudomonas aeruginosa has been linked to severe disease and poor clinical outcomes in animal and human studies. We aimed to investigate whether the ExoS and ExoT effector proteins of P. aeruginosa affect the expression of matrix metalloproteinase 12 (MMP-12) and MMP-13 via nuclear factor κB (NF-κB) signaling pathways. To understand the T3SS, we used ΔExoS, ΔExoT, and ExsA:
Original language | English |
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Pages (from-to) | 962-969 |
Number of pages | 8 |
Journal | Journal of Infectious Diseases |
Volume | 214 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2016 Sep 15 |
Keywords
- MMP-13
- NCI-H292
- NF-κB
- Pneumonia
- Pseudomonas aeruginosa
- matrix metalloproteinase (MMP)-12
- type III secretion system
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases