Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model

Ji Won Park, Yong Jae Kim, In Sik Shin, Ok Kyoung Kwon, Ju Mi Hong, Na Rae Shin, Sei Ryang Oh, Un Hwan Ha, Jae-Hong Kim, Kyung Seop Ahn

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The type III secretion system (T3SS) in Pseudomonas aeruginosa has been linked to severe disease and poor clinical outcomes in animal and human studies. We aimed to investigate whether the ExoS and ExoT effector proteins of P. aeruginosa affect the expression of matrix metalloproteinase 12 (MMP-12) and MMP-13 via nuclear factor κB (NF-κB) signaling pathways. To understand the T3SS, we used ΔExoS, ΔExoT, and ExsA:

Original languageEnglish
Pages (from-to)962-969
Number of pages8
JournalJournal of Infectious Diseases
Volume214
Issue number6
DOIs
Publication statusPublished - 2016 Sep 15

Keywords

  • matrix metalloproteinase (MMP)-12
  • MMP-13
  • NCI-H292
  • NF-κB
  • Pneumonia
  • Pseudomonas aeruginosa
  • type III secretion system

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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