Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model

Ji Won Park; Yong Jae Kim; In Sik Shin; Ok Kyoung Kwon; Ju Mi Hong; Na Rae Shin; Sei Ryang Oh; Un Hwan Ha; Jae Hong Kim; Kyung Seop Ahn

doi:10.1093/infdis/jiw278

Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model

Ji Won Park, Yong Jae Kim, In Sik Shin, Ok Kyoung Kwon, Ju Mi Hong, Na Rae Shin, Sei Ryang Oh, Un Hwan Ha, Jae Hong Kim, Kyung Seop Ahn

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The type III secretion system (T3SS) in Pseudomonas aeruginosa has been linked to severe disease and poor clinical outcomes in animal and human studies. We aimed to investigate whether the ExoS and ExoT effector proteins of P. aeruginosa affect the expression of matrix metalloproteinase 12 (MMP-12) and MMP-13 via nuclear factor κB (NF-κB) signaling pathways. To understand the T3SS, we used ΔExoS, ΔExoT, and ExsA:

Original language	English
Pages (from-to)	962-969
Number of pages	8
Journal	Journal of Infectious Diseases
Volume	214
Issue number	6
DOIs	https://doi.org/10.1093/infdis/jiw278
Publication status	Published - 2016 Sep 15

Keywords

MMP-13
NCI-H292
NF-κB
Pneumonia
Pseudomonas aeruginosa
matrix metalloproteinase (MMP)-12
type III secretion system

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1093/infdis/jiw278

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Park, J. W., Kim, Y. J., Shin, I. S., Kwon, O. K., Hong, J. M., Shin, N. R., Oh, S. R., Ha, U. H., Kim, J. H., & Ahn, K. S. (2016). Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model. Journal of Infectious Diseases, 214(6), 962-969. https://doi.org/10.1093/infdis/jiw278

Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model. / Park, Ji Won; Kim, Yong Jae; Shin, In Sik; Kwon, Ok Kyoung; Hong, Ju Mi; Shin, Na Rae; Oh, Sei Ryang; Ha, Un Hwan; Kim, Jae Hong; Ahn, Kyung Seop.

In: Journal of Infectious Diseases, Vol. 214, No. 6, 15.09.2016, p. 962-969.

Research output: Contribution to journal › Article › peer-review

Park, JW, Kim, YJ, Shin, IS, Kwon, OK, Hong, JM, Shin, NR, Oh, SR, Ha, UH, Kim, JH & Ahn, KS 2016, 'Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model', Journal of Infectious Diseases, vol. 214, no. 6, pp. 962-969. https://doi.org/10.1093/infdis/jiw278

Park JW, Kim YJ, Shin IS, Kwon OK, Hong JM, Shin NR et al. Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model. Journal of Infectious Diseases. 2016 Sep 15;214(6):962-969. https://doi.org/10.1093/infdis/jiw278

Park, Ji Won ; Kim, Yong Jae ; Shin, In Sik ; Kwon, Ok Kyoung ; Hong, Ju Mi ; Shin, Na Rae ; Oh, Sei Ryang ; Ha, Un Hwan ; Kim, Jae Hong ; Ahn, Kyung Seop. / Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model. In: Journal of Infectious Diseases. 2016 ; Vol. 214, No. 6. pp. 962-969.

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abstract = "The type III secretion system (T3SS) in Pseudomonas aeruginosa has been linked to severe disease and poor clinical outcomes in animal and human studies. We aimed to investigate whether the ExoS and ExoT effector proteins of P. aeruginosa affect the expression of matrix metalloproteinase 12 (MMP-12) and MMP-13 via nuclear factor κB (NF-κB) signaling pathways. To understand the T3SS, we used ΔExoS, ΔExoT, and ExsA:",

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author = "Park, {Ji Won} and Kim, {Yong Jae} and Shin, {In Sik} and Kwon, {Ok Kyoung} and Hong, {Ju Mi} and Shin, {Na Rae} and Oh, {Sei Ryang} and Ha, {Un Hwan} and Kim, {Jae Hong} and Ahn, {Kyung Seop}",

note = "Funding Information: This work was supported by the International Broad Material Research Center, funded by the Ministry of Health and Welfare (HI14C1277) and awarded to the Korea Research Institute of Bioscience and Biotechnology Research Initiative Program (KGM 1221622) of the Republic of Korea.",

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