TY - JOUR
T1 - U-shaped association between sleep duration and urinary albumin excretion in Korean adults
T2 - 2011-2014 Korea National Health and Nutrition Examination Survey
AU - Yu, Ji Hee
AU - Han, Kyungdo
AU - Kim, Nam Hoon
AU - Yoo, Hye Jin
AU - Seo, Ji A.
AU - Kim, Sin Gon
AU - Choi, Kyung Mook
AU - Baik, Sei Hyun
AU - Kim, Nan Hee
N1 - Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP), (No. 2015R1A2A2A01003167 to NHK, 2015R1C1A2A01052010); and the Korea University Grant (K1421551) to NHK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP), (No. 2015R1A2A2A01003167, 2015R1C1A2A01052010); and the Korea University Grant (K1421551).
Funding Information:
Funding:Thisresearchwassupportedbythe NationalResearchFoundationofKorea(NRF)grant fundedbytheKoreangovernment(MSIP),(No. 2015R1A2A2A01003167toNHK,
Funding Information:
ThisresearchwassupportedbytheNationalResearchFoundationofKorea(NRF)grant fundedbytheKoreangovernment(MSIP),(No.2015R1A2A2A01003167, 2015R1C1A2A01052010);andtheKoreaUniversityGrant(K1421551).
Publisher Copyright:
© 2018 Yu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2018/2
Y1 - 2018/2
N2 - Although sleep duration has been extensively studied in metabolic diseases, few studies have investigated the impact of sleep duration on chronic kidney disease. The aim of this study was to examine the relationship between sleep duration and albuminuria in the general population. Among 24,948 adults who participated in the 2011–2014 KNHANES, a total of 19,994 subjects were included in this analysis. Subjects were categorized into the following five groups according to self-reported sleep duration: less than 5 h, 6 h, 7 h, 8 h, and more than 9 h. The association between sleep duration and urinary albumin-creatinine ratio (UACR) was examined cross-sectionally. Subjects with both short and long sleep durations were significantly associated with higher UACR levels and higher proportions of patients with microalbuminuria (30–299 mg/g) and macroalbuminuria (300 mg/g) compared to those with a sleep duration of 7 hours. The U-shaped association between sleep duration and UACR remained significant even after adjustment for potential confounders, including age, sex, body mass index, smoking, alcohol, education, income, exercise, estimated glomerular filtration rate, diabetes mellitus, hypertension and hypercholesterolemia. The U-shaped association is more evident in the subgroup aged 65 or older, or in female subjects. Our findings suggest that both short and long sleep durations have a U-shaped association with UACR levels in the general population, independent of potential confounders.
AB - Although sleep duration has been extensively studied in metabolic diseases, few studies have investigated the impact of sleep duration on chronic kidney disease. The aim of this study was to examine the relationship between sleep duration and albuminuria in the general population. Among 24,948 adults who participated in the 2011–2014 KNHANES, a total of 19,994 subjects were included in this analysis. Subjects were categorized into the following five groups according to self-reported sleep duration: less than 5 h, 6 h, 7 h, 8 h, and more than 9 h. The association between sleep duration and urinary albumin-creatinine ratio (UACR) was examined cross-sectionally. Subjects with both short and long sleep durations were significantly associated with higher UACR levels and higher proportions of patients with microalbuminuria (30–299 mg/g) and macroalbuminuria (300 mg/g) compared to those with a sleep duration of 7 hours. The U-shaped association between sleep duration and UACR remained significant even after adjustment for potential confounders, including age, sex, body mass index, smoking, alcohol, education, income, exercise, estimated glomerular filtration rate, diabetes mellitus, hypertension and hypercholesterolemia. The U-shaped association is more evident in the subgroup aged 65 or older, or in female subjects. Our findings suggest that both short and long sleep durations have a U-shaped association with UACR levels in the general population, independent of potential confounders.
UR - http://www.scopus.com/inward/record.url?scp=85042442041&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0192980
DO - 10.1371/journal.pone.0192980
M3 - Article
C2 - 29470498
AN - SCOPUS:85042442041
VL - 13
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 2
M1 - e0192980
ER -