Ubiquinone synthesis by Pneumocystis carinii: Incorporation of radiolabeled polyprenyl chain and benzoquinone ring precursors

D. Sul, E. S. Kaneshiro

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Radiolabeled mevalonic acid was incorporated in vitro into Pneumocystis carinii ubiquinone homologs, CoQ9 and CoQ10, demonstrating the isoprenoid branch pathway forming the polyprenyl chain of ubiquinone is functional in the organism. Radiolabeled shikimic acid, tyrosine and p-hydroxybenzoic acid were also incorporated into the two ubiquinone homologs, indicating that P. carinii also possessed the biochemical pathway for de novo synthesis of the CoQ benzoquinone ring.

Original languageEnglish
Pages (from-to)60S
JournalJournal of Eukaryotic Microbiology
Volume44
Issue number6
Publication statusPublished - 1997 Nov

Keywords

  • Atovavaquone
  • Chorisnate
  • Mevalonate
  • Shikimate
  • Tyrosine
  • p-hydroxybenzoate

ASJC Scopus subject areas

  • Microbiology

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