Abstract
Radiolabeled mevalonic acid was incorporated in vitro into Pneumocystis carinii ubiquinone homologs, CoQ9 and CoQ10, demonstrating the isoprenoid branch pathway forming the polyprenyl chain of ubiquinone is functional in the organism. Radiolabeled shikimic acid, tyrosine and p-hydroxybenzoic acid were also incorporated into the two ubiquinone homologs, indicating that P. carinii also possessed the biochemical pathway for de novo synthesis of the CoQ benzoquinone ring.
| Original language | English |
|---|---|
| Journal | Journal of Eukaryotic Microbiology |
| Volume | 44 |
| Issue number | 6 |
| Publication status | Published - 1997 Nov 1 |
| Externally published | Yes |
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Keywords
- Atovavaquone
- Chorisnate
- Mevalonate
- p-hydroxybenzoate
- Shikimate
- Tyrosine
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Agricultural and Biological Sciences (miscellaneous)
- Applied Microbiology and Biotechnology
- Microbiology
Cite this
Ubiquinone synthesis by Pneumocystis carinii : Incorporation of radiolabeled polyprenyl chain and benzoquinone ring precursors. / Sul, Dong Geun; Kaneshiro, E. S.
In: Journal of Eukaryotic Microbiology, Vol. 44, No. 6, 01.11.1997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ubiquinone synthesis by Pneumocystis carinii
T2 - Incorporation of radiolabeled polyprenyl chain and benzoquinone ring precursors
AU - Sul, Dong Geun
AU - Kaneshiro, E. S.
PY - 1997/11/1
Y1 - 1997/11/1
N2 - Radiolabeled mevalonic acid was incorporated in vitro into Pneumocystis carinii ubiquinone homologs, CoQ9 and CoQ10, demonstrating the isoprenoid branch pathway forming the polyprenyl chain of ubiquinone is functional in the organism. Radiolabeled shikimic acid, tyrosine and p-hydroxybenzoic acid were also incorporated into the two ubiquinone homologs, indicating that P. carinii also possessed the biochemical pathway for de novo synthesis of the CoQ benzoquinone ring.
AB - Radiolabeled mevalonic acid was incorporated in vitro into Pneumocystis carinii ubiquinone homologs, CoQ9 and CoQ10, demonstrating the isoprenoid branch pathway forming the polyprenyl chain of ubiquinone is functional in the organism. Radiolabeled shikimic acid, tyrosine and p-hydroxybenzoic acid were also incorporated into the two ubiquinone homologs, indicating that P. carinii also possessed the biochemical pathway for de novo synthesis of the CoQ benzoquinone ring.
KW - Atovavaquone
KW - Chorisnate
KW - Mevalonate
KW - p-hydroxybenzoate
KW - Shikimate
KW - Tyrosine
UR - http://www.scopus.com/inward/record.url?scp=0031280468&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031280468&partnerID=8YFLogxK
M3 - Article
VL - 44
JO - Journal of Eukaryotic Microbiology
JF - Journal of Eukaryotic Microbiology
SN - 1066-5234
IS - 6
ER -