Abstract
Radiolabeled mevalonic acid was incorporated in vitro into Pneumocystis carinii ubiquinone homologs, CoQ9 and CoQ10, demonstrating the isoprenoid branch pathway forming the polyprenyl chain of ubiquinone is functional in the organism. Radiolabeled shikimic acid, tyrosine and p-hydroxybenzoic acid were also incorporated into the two ubiquinone homologs, indicating that P. carinii also possessed the biochemical pathway for de novo synthesis of the CoQ benzoquinone ring.
| Original language | English |
|---|---|
| Pages (from-to) | 60S |
| Journal | Journal of Eukaryotic Microbiology |
| Volume | 44 |
| Issue number | 6 |
| Publication status | Published - 1997 Nov |
Keywords
- Atovavaquone
- Chorisnate
- Mevalonate
- Shikimate
- Tyrosine
- p-hydroxybenzoate
ASJC Scopus subject areas
- Microbiology
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Sul, D., & Kaneshiro, E. S. (1997). Ubiquinone synthesis by Pneumocystis carinii: Incorporation of radiolabeled polyprenyl chain and benzoquinone ring precursors. Journal of Eukaryotic Microbiology, 44(6), 60S.