Understanding the differentiation, expansion, recruitment and suppressive activities of myeloidderived suppressor cells in cancers

Hui Xuan Lim, Tae Sung Kim, Chit Laa Poh

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

There has been a great interest in myeloid-derived suppressor cells (MDSCs) due to their biological functions in tumor-mediated immune escape by suppressing antitumor immune responses. These cells arise from altered myelopoiesis in response to the tumor-derived factors. The most recognized function of MDSCs is suppressing anti-tumor immune responses by impairing T cell functions, and these cells are the most important players in cancer dissemination and metastasis. Therefore, understanding the factors and the mechanism of MDSC differentiation, expansion, and recruitment into the tumor microenvironment can lead to its control. However, most of the studies only defined MDSCs with no further characterization of granulocytic and monocytic subsets. In this review, we discuss the mechanisms by which specific MDSC subsets contribute to cancers. A better understanding of MDSC subset development and the specific molecular mechanism is needed to identify treatment targets. The understanding of the specific molecular mechanisms responsible for MDSC accumulation would enable more precise therapeutic targeting of these cells.

Original languageEnglish
Article number3599
JournalInternational journal of molecular sciences
Volume21
Issue number10
DOIs
Publication statusPublished - 2020 May 2

Keywords

  • Cancers
  • G-MDSCs
  • Immunosuppression
  • M-MDSCs
  • MDSC subsets

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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