Understanding the pathogenesis of zika virus infection using animal models

Keeton K. Krause, Francine Azouz, Ok Shin, Mukesh Kumar

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Zika virus (ZIKV) is a member of Flaviviridae family that has emerged as a pathogen of significant public health importance. The rapid expansion of ZIKV in the South and Central America has recently gained medical attention emphasizing the capacity of ZIKV to spread to non-endemic regions. ZIKV infection during pregnancy has been demonstrated to cause microcephaly and other fetal developmental abnormalities. An increased incidence of Guillain-Barre syndrome, an immune mediated neuropathy of the peripheral nervous system, has also been reported in ZIKV-infected patients in French Polynesia and Brazil. No effective therapies currently exist for treating patients infected with ZIKV. Despite the relatively short time interval, an intensive effort by the global scientific community has resulted in development of animal models to study multiple aspects of ZIKV biology. Several animal models have been established to investigate pathogenesis of ZIKV in adults, pregnant mothers, and developing fetuses. Here we review the remarkable progress of newly developed small and large animal models for understanding ZIKV pathogenesis.

Original languageEnglish
Pages (from-to)287-297
Number of pages11
JournalImmune Network
Volume17
Issue number5
DOIs
Publication statusPublished - 2017 Oct 1

Fingerprint

Animal Models
Flaviviridae
Polynesia
Central America
Microcephaly
Guillain-Barre Syndrome
Zika Virus Infection
Zika Virus
South America
Peripheral Nervous System
Brazil
Fetus
Public Health
Mothers
Pregnancy
Incidence

Keywords

  • Animal model
  • Etiology
  • Zika virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Understanding the pathogenesis of zika virus infection using animal models. / Krause, Keeton K.; Azouz, Francine; Shin, Ok; Kumar, Mukesh.

In: Immune Network, Vol. 17, No. 5, 01.10.2017, p. 287-297.

Research output: Contribution to journalReview article

Krause, Keeton K. ; Azouz, Francine ; Shin, Ok ; Kumar, Mukesh. / Understanding the pathogenesis of zika virus infection using animal models. In: Immune Network. 2017 ; Vol. 17, No. 5. pp. 287-297.
@article{46a9c178424f4f3788c34c2012eadd3e,
title = "Understanding the pathogenesis of zika virus infection using animal models",
abstract = "Zika virus (ZIKV) is a member of Flaviviridae family that has emerged as a pathogen of significant public health importance. The rapid expansion of ZIKV in the South and Central America has recently gained medical attention emphasizing the capacity of ZIKV to spread to non-endemic regions. ZIKV infection during pregnancy has been demonstrated to cause microcephaly and other fetal developmental abnormalities. An increased incidence of Guillain-Barre syndrome, an immune mediated neuropathy of the peripheral nervous system, has also been reported in ZIKV-infected patients in French Polynesia and Brazil. No effective therapies currently exist for treating patients infected with ZIKV. Despite the relatively short time interval, an intensive effort by the global scientific community has resulted in development of animal models to study multiple aspects of ZIKV biology. Several animal models have been established to investigate pathogenesis of ZIKV in adults, pregnant mothers, and developing fetuses. Here we review the remarkable progress of newly developed small and large animal models for understanding ZIKV pathogenesis.",
keywords = "Animal model, Etiology, Zika virus",
author = "Krause, {Keeton K.} and Francine Azouz and Ok Shin and Mukesh Kumar",
year = "2017",
month = "10",
day = "1",
doi = "10.4110/in.2017.17.5.287",
language = "English",
volume = "17",
pages = "287--297",
journal = "Immune Network",
issn = "1598-2629",
publisher = "Korean Association of Immunologists",
number = "5",

}

TY - JOUR

T1 - Understanding the pathogenesis of zika virus infection using animal models

AU - Krause, Keeton K.

AU - Azouz, Francine

AU - Shin, Ok

AU - Kumar, Mukesh

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Zika virus (ZIKV) is a member of Flaviviridae family that has emerged as a pathogen of significant public health importance. The rapid expansion of ZIKV in the South and Central America has recently gained medical attention emphasizing the capacity of ZIKV to spread to non-endemic regions. ZIKV infection during pregnancy has been demonstrated to cause microcephaly and other fetal developmental abnormalities. An increased incidence of Guillain-Barre syndrome, an immune mediated neuropathy of the peripheral nervous system, has also been reported in ZIKV-infected patients in French Polynesia and Brazil. No effective therapies currently exist for treating patients infected with ZIKV. Despite the relatively short time interval, an intensive effort by the global scientific community has resulted in development of animal models to study multiple aspects of ZIKV biology. Several animal models have been established to investigate pathogenesis of ZIKV in adults, pregnant mothers, and developing fetuses. Here we review the remarkable progress of newly developed small and large animal models for understanding ZIKV pathogenesis.

AB - Zika virus (ZIKV) is a member of Flaviviridae family that has emerged as a pathogen of significant public health importance. The rapid expansion of ZIKV in the South and Central America has recently gained medical attention emphasizing the capacity of ZIKV to spread to non-endemic regions. ZIKV infection during pregnancy has been demonstrated to cause microcephaly and other fetal developmental abnormalities. An increased incidence of Guillain-Barre syndrome, an immune mediated neuropathy of the peripheral nervous system, has also been reported in ZIKV-infected patients in French Polynesia and Brazil. No effective therapies currently exist for treating patients infected with ZIKV. Despite the relatively short time interval, an intensive effort by the global scientific community has resulted in development of animal models to study multiple aspects of ZIKV biology. Several animal models have been established to investigate pathogenesis of ZIKV in adults, pregnant mothers, and developing fetuses. Here we review the remarkable progress of newly developed small and large animal models for understanding ZIKV pathogenesis.

KW - Animal model

KW - Etiology

KW - Zika virus

UR - http://www.scopus.com/inward/record.url?scp=85033230318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033230318&partnerID=8YFLogxK

U2 - 10.4110/in.2017.17.5.287

DO - 10.4110/in.2017.17.5.287

M3 - Review article

AN - SCOPUS:85033230318

VL - 17

SP - 287

EP - 297

JO - Immune Network

JF - Immune Network

SN - 1598-2629

IS - 5

ER -