Understanding tumor heterogeneity as an encourager for cancer metastasis (in vitro model of tumor heterogeneity)

Y. Shin, Seok Chung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Intra-tumor heterogeneity means that there are more than two types of cells that have different subtypes with distinct molecular and gene expressions in a single tumor colony. Tumor heterogeneity is a crucial phenomenon for tumor progression and a main reason of drug resistance. To study the causes and consequences of tumor heterogeneity, most researchers have focused on molecular and genetic association of cancer cells. However, phenotypic events during tumor progression have been barely studied because of the lack of suitable in vitro models. Here, in our study, we developed a in vitro tumor heterogeneity model, capable of emulating 3D microenvironment and heterogeneous condition of tumor, to evaluate the phenotypic phenomena caused in heterogeneous cell population in tumor during metastasis.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages1956-1958
Number of pages3
Volume3
ISBN (Print)9781632666246
Publication statusPublished - 2013 Jan 1
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: 2013 Oct 272013 Oct 31

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period13/10/2713/10/31

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ASJC Scopus subject areas

  • Bioengineering

Cite this

Shin, Y., & Chung, S. (2013). Understanding tumor heterogeneity as an encourager for cancer metastasis (in vitro model of tumor heterogeneity). In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 (Vol. 3, pp. 1956-1958). Chemical and Biological Microsystems Society.