Uniform Microgels Containing Agglomerates of Silver Nanocubes for Molecular Size-Selectivity and High SERS Activity

Dong Jae Kim, Tae Yoon Jeon, Sung Gyu Park, Hye Ji Han, Sang Hyuk Im, Dong Ho Kim, Shin Hyun Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Surface-enhanced Raman scattering (SERS) is a promising technique for molecular analysis as the molecular fingerprints (Raman spectra) are amplified to detectable levels compared with common spectroscopy. Metal nanostructures localize electromagnetic field on their surfaces, which can lead to dramatic increase of Raman intensity of molecules adsorbed. However, the metal surfaces are prone to contamination, thereby requiring pretreatment of samples to remove adhesive molecules. To avoid the pretreatment and potentially achieve point-of-care (POC) analysis, we have developed SERS-active microgels using the droplet-microfluidic system. As the microgels are composed of water-swollen network with consistent mesh size, they selectively allow diffusion of molecules smaller than the mesh, thereby excluding large adhesives. To render the microgels highly SERS-active, we destabilize silver nanocubes to form agglomerates, which are embedded in the matrix of microgels. The nanogaps in the agglomerates provide high sensitivity in Raman measurement and size-selective permeability of the microgel matrix obviates the pretreatment of samples. To validate the functions, we demonstrate the direct detection of Aspirin dissolved in whole blood without any pretreatment.

Original languageEnglish
Article number1604048
JournalSmall
Volume13
Issue number23
DOIs
Publication statusPublished - 2017 Jun 20

Fingerprint

Raman Spectrum Analysis
Silver
Raman scattering
Adhesives
Metals
Point-of-Care Systems
Electromagnetic Fields
Microfluidics
Nanostructures
Molecules
Dermatoglyphics
Aspirin
Permeability
Spectrum Analysis
Water
Electromagnetic fields
Contamination
Blood
Spectroscopy

Keywords

  • agglomerates
  • hydrogels
  • microfluidics
  • semipermeable
  • surface-enhanced Raman scattering

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)
  • Engineering (miscellaneous)

Cite this

Uniform Microgels Containing Agglomerates of Silver Nanocubes for Molecular Size-Selectivity and High SERS Activity. / Kim, Dong Jae; Jeon, Tae Yoon; Park, Sung Gyu; Han, Hye Ji; Im, Sang Hyuk; Kim, Dong Ho; Kim, Shin Hyun.

In: Small, Vol. 13, No. 23, 1604048, 20.06.2017.

Research output: Contribution to journalArticle

Kim, Dong Jae ; Jeon, Tae Yoon ; Park, Sung Gyu ; Han, Hye Ji ; Im, Sang Hyuk ; Kim, Dong Ho ; Kim, Shin Hyun. / Uniform Microgels Containing Agglomerates of Silver Nanocubes for Molecular Size-Selectivity and High SERS Activity. In: Small. 2017 ; Vol. 13, No. 23.
@article{1aae9d2a7a144088bec692b613a28a0f,
title = "Uniform Microgels Containing Agglomerates of Silver Nanocubes for Molecular Size-Selectivity and High SERS Activity",
abstract = "Surface-enhanced Raman scattering (SERS) is a promising technique for molecular analysis as the molecular fingerprints (Raman spectra) are amplified to detectable levels compared with common spectroscopy. Metal nanostructures localize electromagnetic field on their surfaces, which can lead to dramatic increase of Raman intensity of molecules adsorbed. However, the metal surfaces are prone to contamination, thereby requiring pretreatment of samples to remove adhesive molecules. To avoid the pretreatment and potentially achieve point-of-care (POC) analysis, we have developed SERS-active microgels using the droplet-microfluidic system. As the microgels are composed of water-swollen network with consistent mesh size, they selectively allow diffusion of molecules smaller than the mesh, thereby excluding large adhesives. To render the microgels highly SERS-active, we destabilize silver nanocubes to form agglomerates, which are embedded in the matrix of microgels. The nanogaps in the agglomerates provide high sensitivity in Raman measurement and size-selective permeability of the microgel matrix obviates the pretreatment of samples. To validate the functions, we demonstrate the direct detection of Aspirin dissolved in whole blood without any pretreatment.",
keywords = "agglomerates, hydrogels, microfluidics, semipermeable, surface-enhanced Raman scattering",
author = "Kim, {Dong Jae} and Jeon, {Tae Yoon} and Park, {Sung Gyu} and Han, {Hye Ji} and Im, {Sang Hyuk} and Kim, {Dong Ho} and Kim, {Shin Hyun}",
year = "2017",
month = "6",
day = "20",
doi = "10.1002/smll.201604048",
language = "English",
volume = "13",
journal = "Small",
issn = "1613-6810",
publisher = "Wiley-VCH Verlag",
number = "23",

}

TY - JOUR

T1 - Uniform Microgels Containing Agglomerates of Silver Nanocubes for Molecular Size-Selectivity and High SERS Activity

AU - Kim, Dong Jae

AU - Jeon, Tae Yoon

AU - Park, Sung Gyu

AU - Han, Hye Ji

AU - Im, Sang Hyuk

AU - Kim, Dong Ho

AU - Kim, Shin Hyun

PY - 2017/6/20

Y1 - 2017/6/20

N2 - Surface-enhanced Raman scattering (SERS) is a promising technique for molecular analysis as the molecular fingerprints (Raman spectra) are amplified to detectable levels compared with common spectroscopy. Metal nanostructures localize electromagnetic field on their surfaces, which can lead to dramatic increase of Raman intensity of molecules adsorbed. However, the metal surfaces are prone to contamination, thereby requiring pretreatment of samples to remove adhesive molecules. To avoid the pretreatment and potentially achieve point-of-care (POC) analysis, we have developed SERS-active microgels using the droplet-microfluidic system. As the microgels are composed of water-swollen network with consistent mesh size, they selectively allow diffusion of molecules smaller than the mesh, thereby excluding large adhesives. To render the microgels highly SERS-active, we destabilize silver nanocubes to form agglomerates, which are embedded in the matrix of microgels. The nanogaps in the agglomerates provide high sensitivity in Raman measurement and size-selective permeability of the microgel matrix obviates the pretreatment of samples. To validate the functions, we demonstrate the direct detection of Aspirin dissolved in whole blood without any pretreatment.

AB - Surface-enhanced Raman scattering (SERS) is a promising technique for molecular analysis as the molecular fingerprints (Raman spectra) are amplified to detectable levels compared with common spectroscopy. Metal nanostructures localize electromagnetic field on their surfaces, which can lead to dramatic increase of Raman intensity of molecules adsorbed. However, the metal surfaces are prone to contamination, thereby requiring pretreatment of samples to remove adhesive molecules. To avoid the pretreatment and potentially achieve point-of-care (POC) analysis, we have developed SERS-active microgels using the droplet-microfluidic system. As the microgels are composed of water-swollen network with consistent mesh size, they selectively allow diffusion of molecules smaller than the mesh, thereby excluding large adhesives. To render the microgels highly SERS-active, we destabilize silver nanocubes to form agglomerates, which are embedded in the matrix of microgels. The nanogaps in the agglomerates provide high sensitivity in Raman measurement and size-selective permeability of the microgel matrix obviates the pretreatment of samples. To validate the functions, we demonstrate the direct detection of Aspirin dissolved in whole blood without any pretreatment.

KW - agglomerates

KW - hydrogels

KW - microfluidics

KW - semipermeable

KW - surface-enhanced Raman scattering

UR - http://www.scopus.com/inward/record.url?scp=85019010408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019010408&partnerID=8YFLogxK

U2 - 10.1002/smll.201604048

DO - 10.1002/smll.201604048

M3 - Article

VL - 13

JO - Small

JF - Small

SN - 1613-6810

IS - 23

M1 - 1604048

ER -