Unmet treatment needs of gastroesophageal reflux disease in Asia: Gastroesophageal reflux disease in Asia Pacific Survey

Khean Lee Goh, Myung Gyu Choi, William Ping I. Hsu, Hoon-Jai Chun, Varocha Mahachai, Udom Kachintorn, Somchai Leelakusolvong, Nayoung Kim, Abdul Aziz Rani, Benjamin Cy Wong, Justin Wu, Cheng Tang Chiu, Romeo Chu, Vikram Shetty, Joseph C. Bocobo, Melchor M. Chan, Jaw Town Lin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background and Aim: Data on patient satisfaction with proton pump inhibitor (PPI) therapy for gastroesophageal reflux disease (GERD) are scarce in Asia. The perspectives of Asian patients with GERD and their satisfaction with PPI therapy were investigated. Methods: The GERD in Asia Pacific Survey (GAPS) was conducted from December 2011 to March 2012. Patients aged 21-55 years with self-reported doctor-diagnosed GERD, who had experienced symptoms in the previous 12 months, and were currently taking PPIs were enrolled. After a pilot study, a questionnaire was completed by respondents from six Asian countries during face-to-face interviews. Results: A total of 450 patients with GERD participated in the GAPS. Although the respondents generally complied with treatment, response to therapy was only partially successful. Most respondents indicated that PPIs eliminated pain (72%), took effect within 30min (76%), provided sustained relief (73%), and provided nocturnal relief (77%). However, 45% of respondents reported limited improvement in nocturnal symptoms, and 49% continued to take adjunctive therapy to manage their symptoms. After treatment, respondent's "well-being" had improved. However, GERD still had a negative impact on well-being for 76% of respondents after treatment, compared with 94% before treatment. Conclusions: Asian patients reported a negative impact of GERD on their daily lives. Many respondents continued to experience symptoms despite reporting good compliance with PPI therapy, emphasizing the shortcomings of currently available therapy for GERD. This survey is the first to highlight Asian patients' perspectives of GERD and PPI therapy, and provides a platform for further evaluation.

Original languageEnglish
Pages (from-to)1969-1975
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume29
Issue number12
DOIs
Publication statusPublished - 2014 Jan 1

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Gastroesophageal Reflux
Proton Pump Inhibitors
Therapeutics
Surveys and Questionnaires
Patient Satisfaction
Interviews
Pain

Keywords

  • Abdominal pain
  • Asia
  • Gastroesophageal reflux
  • Heartburn
  • Proton pump inhibitors

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Unmet treatment needs of gastroesophageal reflux disease in Asia : Gastroesophageal reflux disease in Asia Pacific Survey. / Goh, Khean Lee; Choi, Myung Gyu; Hsu, William Ping I.; Chun, Hoon-Jai; Mahachai, Varocha; Kachintorn, Udom; Leelakusolvong, Somchai; Kim, Nayoung; Rani, Abdul Aziz; Wong, Benjamin Cy; Wu, Justin; Chiu, Cheng Tang; Chu, Romeo; Shetty, Vikram; Bocobo, Joseph C.; Chan, Melchor M.; Lin, Jaw Town.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 29, No. 12, 01.01.2014, p. 1969-1975.

Research output: Contribution to journalArticle

Goh, KL, Choi, MG, Hsu, WPI, Chun, H-J, Mahachai, V, Kachintorn, U, Leelakusolvong, S, Kim, N, Rani, AA, Wong, BC, Wu, J, Chiu, CT, Chu, R, Shetty, V, Bocobo, JC, Chan, MM & Lin, JT 2014, 'Unmet treatment needs of gastroesophageal reflux disease in Asia: Gastroesophageal reflux disease in Asia Pacific Survey', Journal of Gastroenterology and Hepatology (Australia), vol. 29, no. 12, pp. 1969-1975. https://doi.org/10.1111/jgh.12655
Goh, Khean Lee ; Choi, Myung Gyu ; Hsu, William Ping I. ; Chun, Hoon-Jai ; Mahachai, Varocha ; Kachintorn, Udom ; Leelakusolvong, Somchai ; Kim, Nayoung ; Rani, Abdul Aziz ; Wong, Benjamin Cy ; Wu, Justin ; Chiu, Cheng Tang ; Chu, Romeo ; Shetty, Vikram ; Bocobo, Joseph C. ; Chan, Melchor M. ; Lin, Jaw Town. / Unmet treatment needs of gastroesophageal reflux disease in Asia : Gastroesophageal reflux disease in Asia Pacific Survey. In: Journal of Gastroenterology and Hepatology (Australia). 2014 ; Vol. 29, No. 12. pp. 1969-1975.
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abstract = "Background and Aim: Data on patient satisfaction with proton pump inhibitor (PPI) therapy for gastroesophageal reflux disease (GERD) are scarce in Asia. The perspectives of Asian patients with GERD and their satisfaction with PPI therapy were investigated. Methods: The GERD in Asia Pacific Survey (GAPS) was conducted from December 2011 to March 2012. Patients aged 21-55 years with self-reported doctor-diagnosed GERD, who had experienced symptoms in the previous 12 months, and were currently taking PPIs were enrolled. After a pilot study, a questionnaire was completed by respondents from six Asian countries during face-to-face interviews. Results: A total of 450 patients with GERD participated in the GAPS. Although the respondents generally complied with treatment, response to therapy was only partially successful. Most respondents indicated that PPIs eliminated pain (72{\%}), took effect within 30min (76{\%}), provided sustained relief (73{\%}), and provided nocturnal relief (77{\%}). However, 45{\%} of respondents reported limited improvement in nocturnal symptoms, and 49{\%} continued to take adjunctive therapy to manage their symptoms. After treatment, respondent's {"}well-being{"} had improved. However, GERD still had a negative impact on well-being for 76{\%} of respondents after treatment, compared with 94{\%} before treatment. Conclusions: Asian patients reported a negative impact of GERD on their daily lives. Many respondents continued to experience symptoms despite reporting good compliance with PPI therapy, emphasizing the shortcomings of currently available therapy for GERD. This survey is the first to highlight Asian patients' perspectives of GERD and PPI therapy, and provides a platform for further evaluation.",
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AU - Choi, Myung Gyu

AU - Hsu, William Ping I.

AU - Chun, Hoon-Jai

AU - Mahachai, Varocha

AU - Kachintorn, Udom

AU - Leelakusolvong, Somchai

AU - Kim, Nayoung

AU - Rani, Abdul Aziz

AU - Wong, Benjamin Cy

AU - Wu, Justin

AU - Chiu, Cheng Tang

AU - Chu, Romeo

AU - Shetty, Vikram

AU - Bocobo, Joseph C.

AU - Chan, Melchor M.

AU - Lin, Jaw Town

PY - 2014/1/1

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N2 - Background and Aim: Data on patient satisfaction with proton pump inhibitor (PPI) therapy for gastroesophageal reflux disease (GERD) are scarce in Asia. The perspectives of Asian patients with GERD and their satisfaction with PPI therapy were investigated. Methods: The GERD in Asia Pacific Survey (GAPS) was conducted from December 2011 to March 2012. Patients aged 21-55 years with self-reported doctor-diagnosed GERD, who had experienced symptoms in the previous 12 months, and were currently taking PPIs were enrolled. After a pilot study, a questionnaire was completed by respondents from six Asian countries during face-to-face interviews. Results: A total of 450 patients with GERD participated in the GAPS. Although the respondents generally complied with treatment, response to therapy was only partially successful. Most respondents indicated that PPIs eliminated pain (72%), took effect within 30min (76%), provided sustained relief (73%), and provided nocturnal relief (77%). However, 45% of respondents reported limited improvement in nocturnal symptoms, and 49% continued to take adjunctive therapy to manage their symptoms. After treatment, respondent's "well-being" had improved. However, GERD still had a negative impact on well-being for 76% of respondents after treatment, compared with 94% before treatment. Conclusions: Asian patients reported a negative impact of GERD on their daily lives. Many respondents continued to experience symptoms despite reporting good compliance with PPI therapy, emphasizing the shortcomings of currently available therapy for GERD. This survey is the first to highlight Asian patients' perspectives of GERD and PPI therapy, and provides a platform for further evaluation.

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KW - Asia

KW - Gastroesophageal reflux

KW - Heartburn

KW - Proton pump inhibitors

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