Unraveling the Mechanobiology of the Immune System

Jeong Ki Kim, Yu Jung Shin, Leslie Jaesun Ha, Deok Ho Kim, Dong-Hwee Kim

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Cells respond and actively adapt to environmental cues in the form of mechanical stimuli. This extends to immune cells and their critical role in the maintenance of tissue homeostasis. Multiple recent studies have begun illuminating underlying mechanisms of mechanosensation in modulating immune cell phenotypes. Since the extracellular microenvironment is critical to modify cellular physiology that ultimately determines the functionality of the cell, understanding the interactions between immune cells and their microenvironment is necessary. This review focuses on mechanoregulation of immune responses mediated by macrophages, dendritic cells, and T cells, in the context of modern mechanobiology.

Original languageEnglish
Article number1801332
JournalAdvanced Healthcare Materials
Volume8
Issue number4
DOIs
Publication statusPublished - 2019 Feb 21

Keywords

  • immune cells
  • immune response
  • mechanobiology
  • mechanoregulation

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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