TY - JOUR
T1 - Unraveling the physiological roles of retinoic acid receptor-related orphan receptor α
AU - Lee, Ji Min
AU - Kim, Hyunkyung
AU - Baek, Sung Hee
N1 - Funding Information:
This study was supported by the Creative Research Initiatives Program (Research Center for Epigenetics Code and Diseases, NRF-2017R1A3B1023387) and Samsung Research Funding & Incubation Center of Samsung Electronics (SRFC-MA1502-51) to S.H.B., the Basic Science Research Program (NRF-2021R1C1C1008780) to J.M.L., and the Basic Science Research Program (NRF-2020R1C1C1010489) to H.K., from the National Research Foundation (NRF) grant funded by the Korean government. The figures were generated using BioRender, with a paid license for publication.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/9
Y1 - 2021/9
N2 - Retinoic acid receptor-related orphan receptor-α (RORα) is a member of the orphan nuclear receptor family and functions as a transcriptional activator in response to circadian changes. Circadian rhythms are complex cellular mechanisms regulating diverse metabolic, inflammatory, and tumorigenic gene expression pathways that govern cyclic cellular physiology. Disruption of circadian regulators, including RORα, plays a critical role in tumorigenesis and facilitates the development of inflammatory hallmarks. Although RORα contributes to overall fitness among anticancer, anti-inflammatory, lipid homeostasis, and circadian clock mechanisms, the molecular mechanisms underlying the mode of transcriptional regulation by RORα remain unclear. Nonetheless, RORα has important implications for pharmacological prevention of cancer, inflammation, and metabolic diseases, and understanding context-dependent RORα regulation will provide an innovative approach for unraveling the functional link between cancer metabolism and rhythm changes.
AB - Retinoic acid receptor-related orphan receptor-α (RORα) is a member of the orphan nuclear receptor family and functions as a transcriptional activator in response to circadian changes. Circadian rhythms are complex cellular mechanisms regulating diverse metabolic, inflammatory, and tumorigenic gene expression pathways that govern cyclic cellular physiology. Disruption of circadian regulators, including RORα, plays a critical role in tumorigenesis and facilitates the development of inflammatory hallmarks. Although RORα contributes to overall fitness among anticancer, anti-inflammatory, lipid homeostasis, and circadian clock mechanisms, the molecular mechanisms underlying the mode of transcriptional regulation by RORα remain unclear. Nonetheless, RORα has important implications for pharmacological prevention of cancer, inflammation, and metabolic diseases, and understanding context-dependent RORα regulation will provide an innovative approach for unraveling the functional link between cancer metabolism and rhythm changes.
UR - http://www.scopus.com/inward/record.url?scp=85116049727&partnerID=8YFLogxK
U2 - 10.1038/s12276-021-00679-8
DO - 10.1038/s12276-021-00679-8
M3 - Review article
AN - SCOPUS:85116049727
VL - 53
SP - 1278
EP - 1286
JO - Experimental and Molecular Medicine
JF - Experimental and Molecular Medicine
SN - 1226-3613
IS - 9
ER -
