Unsaponifiable Matter from Rice Bran Attenuates High Glucose-Induced Lipid Accumulation by Activating AMPK in HepG2 Cells

Hyeonmi Ham, Koan Sik Woo, Yu Young Lee, Byongwon Lee, In-Hwan Kim, Junsoo Lee

Research output: Contribution to journalArticle

Abstract

Rice bran, a major by-product of rice milling, has a variety of health benefits, including antioxidant, anti-inflammatory, and cholesterol-lowering effects. However, the effects of rice bran unsaponifiable matter (USM) on hepatic lipid metabolism remain unclear. In this study, the effects of rice bran USM in the prevention of high glucose-induced lipid accumulation and its putative mechanism in HepG2 cells were investigated. USM significantly inhibited high glucose-induced lipid accumulation and suppressed fatty acid synthase and sterol regulatory element-binding protein-1c expression in HepG2 cells. It also increased the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl coenzyme A carboxylase. Moreover, a specific inhibitor of AMPK attenuated the effects of USM on lipid accumulation. These results demonstrate that rice bran USM prevents hepatic lipid accumulation via an AMPK-dependent signaling pathway and provides a promising approach for novel lipid-lowering therapies.

Original languageEnglish
JournalJournal of Food Biochemistry
DOIs
Publication statusAccepted/In press - 2016

ASJC Scopus subject areas

  • Food Science
  • Biophysics
  • Pharmacology
  • Cell Biology

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