Unusual bridged angucyclinones and potent anticancer compounds from: Streptomyces bulli GJA1

Jung Wha Kim, Yun Kwon, Sunghee Bang, Ha Eun Kwon, Sunwoo Park, Yeonhee Lee, Stephen T. Deyrup, Gwonhwa Song, Dongho Lee, Hwang Soo Joo, Sang Hee Shim

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Two new unique angucyclinones (1 and 2) with unprecedented ether bridges connecting carbons 5 and 7 were isolated from the cultures of Streptomyces bulli GJA1, an endophyte of Gardenia jasminoides, together with two known ones (3 and 4). The MS2-based molecular networking system facilitated the isolation of compounds with target functionalities. The stereochemistry of 1 was completely established by ROESY and ECD experiments. Compound 3 showed antivirulence activities by inhibiting the peptide toxin (PSMs) production and the biofilm formation of MRSA. Compounds 3 and 4 showed very potent anti-proliferative effects against OV1 and ES2 ovarian cancer cells. This journal is

Original languageEnglish
Pages (from-to)8443-8449
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume18
Issue number41
DOIs
Publication statusPublished - 2020 Nov 7

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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