Up-regulation of protease-activated receptor 2 in allergic rhinitis

Heung Man Lee; Yeol Kim Hyo; Joon Kang Hee; Soo Woo Jeong; Won Chae Sung; Hag Lee Sang; Jae Hwang Soon

doi:10.1177/000348940711600712

Up-regulation of protease-activated receptor 2 in allergic rhinitis

Heung Man Lee, Yeol Kim Hyo, Joon Kang Hee, Soo Woo Jeong, Won Chae Sung, Hag Lee Sang, Jae Hwang Soon

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Objectives: We compared the patterns of PAR-2 messenger RNA (mRNA) and protein expression in the nasal mucosa of subjects with and without allergic rhinitis. Methods: Biopsy specimens were obtained from 10 patients with allergic rhinitis and 10 normal controls. RNA was extracted from the nasal mucosa, and semiquantitative reverse transcription-polymerase chain reaction was performed for PAR-2. Tissue sections were immunostained for PAR-2 by use of specific antibody. Results: The expression levels of PAR-2 mRNA in allergic rhinitis nasal mucosa were significantly up-regulated as compared with those in normal nasal mucosa. PAR-2 immunoreactivity was observed in the epithelium and submucosal glands in both normal controls and subjects with allergic rhinitis. Stronger immunoreactivity for PAR-2 was observed in allergic rhinitis nasal mucosa as compared with normal nasal mucosa. Conclusions: These results suggest that PAR-2 may be involved in allergic nasal inflammation.

Original language	English
Pages (from-to)	554-558
Number of pages	5
Journal	Annals of Otology, Rhinology and Laryngology
Volume	116
Issue number	7
DOIs	https://doi.org/10.1177/000348940711600712
Publication status	Published - 2007 Jul

Keywords

Allergic rhinitis
Protease-activated receptor

ASJC Scopus subject areas

Otorhinolaryngology

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title = "Up-regulation of protease-activated receptor 2 in allergic rhinitis",

abstract = "Objectives: We compared the patterns of PAR-2 messenger RNA (mRNA) and protein expression in the nasal mucosa of subjects with and without allergic rhinitis. Methods: Biopsy specimens were obtained from 10 patients with allergic rhinitis and 10 normal controls. RNA was extracted from the nasal mucosa, and semiquantitative reverse transcription-polymerase chain reaction was performed for PAR-2. Tissue sections were immunostained for PAR-2 by use of specific antibody. Results: The expression levels of PAR-2 mRNA in allergic rhinitis nasal mucosa were significantly up-regulated as compared with those in normal nasal mucosa. PAR-2 immunoreactivity was observed in the epithelium and submucosal glands in both normal controls and subjects with allergic rhinitis. Stronger immunoreactivity for PAR-2 was observed in allergic rhinitis nasal mucosa as compared with normal nasal mucosa. Conclusions: These results suggest that PAR-2 may be involved in allergic nasal inflammation.",

keywords = "Allergic rhinitis, Protease-activated receptor",

author = "Lee, {Heung Man} and Hyo, {Yeol Kim} and Hee, {Joon Kang} and Jeong, {Soo Woo} and Sung, {Won Chae} and Sang, {Hag Lee} and Soon, {Jae Hwang}",

year = "2007",

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doi = "10.1177/000348940711600712",

language = "English",

volume = "116",

pages = "554--558",

journal = "Annals of Otology, Rhinology and Laryngology",

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T1 - Up-regulation of protease-activated receptor 2 in allergic rhinitis

AU - Lee, Heung Man

AU - Hyo, Yeol Kim

AU - Hee, Joon Kang

AU - Jeong, Soo Woo

AU - Sung, Won Chae

AU - Sang, Hag Lee

AU - Soon, Jae Hwang

PY - 2007/7

Y1 - 2007/7

N2 - Objectives: We compared the patterns of PAR-2 messenger RNA (mRNA) and protein expression in the nasal mucosa of subjects with and without allergic rhinitis. Methods: Biopsy specimens were obtained from 10 patients with allergic rhinitis and 10 normal controls. RNA was extracted from the nasal mucosa, and semiquantitative reverse transcription-polymerase chain reaction was performed for PAR-2. Tissue sections were immunostained for PAR-2 by use of specific antibody. Results: The expression levels of PAR-2 mRNA in allergic rhinitis nasal mucosa were significantly up-regulated as compared with those in normal nasal mucosa. PAR-2 immunoreactivity was observed in the epithelium and submucosal glands in both normal controls and subjects with allergic rhinitis. Stronger immunoreactivity for PAR-2 was observed in allergic rhinitis nasal mucosa as compared with normal nasal mucosa. Conclusions: These results suggest that PAR-2 may be involved in allergic nasal inflammation.

AB - Objectives: We compared the patterns of PAR-2 messenger RNA (mRNA) and protein expression in the nasal mucosa of subjects with and without allergic rhinitis. Methods: Biopsy specimens were obtained from 10 patients with allergic rhinitis and 10 normal controls. RNA was extracted from the nasal mucosa, and semiquantitative reverse transcription-polymerase chain reaction was performed for PAR-2. Tissue sections were immunostained for PAR-2 by use of specific antibody. Results: The expression levels of PAR-2 mRNA in allergic rhinitis nasal mucosa were significantly up-regulated as compared with those in normal nasal mucosa. PAR-2 immunoreactivity was observed in the epithelium and submucosal glands in both normal controls and subjects with allergic rhinitis. Stronger immunoreactivity for PAR-2 was observed in allergic rhinitis nasal mucosa as compared with normal nasal mucosa. Conclusions: These results suggest that PAR-2 may be involved in allergic nasal inflammation.

KW - Allergic rhinitis

KW - Protease-activated receptor

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