Up-regulation of protease-activated receptor 2 in allergic rhinitis

Heung Man Lee, Yeol Kim Hyo, Joon Kang Hee, Jeong-Soo Woo, Sungwon Chae, Sang Hag Lee, Jae Hwang Soon

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives: We compared the patterns of PAR-2 messenger RNA (mRNA) and protein expression in the nasal mucosa of subjects with and without allergic rhinitis. Methods: Biopsy specimens were obtained from 10 patients with allergic rhinitis and 10 normal controls. RNA was extracted from the nasal mucosa, and semiquantitative reverse transcription-polymerase chain reaction was performed for PAR-2. Tissue sections were immunostained for PAR-2 by use of specific antibody. Results: The expression levels of PAR-2 mRNA in allergic rhinitis nasal mucosa were significantly up-regulated as compared with those in normal nasal mucosa. PAR-2 immunoreactivity was observed in the epithelium and submucosal glands in both normal controls and subjects with allergic rhinitis. Stronger immunoreactivity for PAR-2 was observed in allergic rhinitis nasal mucosa as compared with normal nasal mucosa. Conclusions: These results suggest that PAR-2 may be involved in allergic nasal inflammation.

Original languageEnglish
Pages (from-to)554-558
Number of pages5
JournalAnnals of Otology, Rhinology and Laryngology
Volume116
Issue number7
Publication statusPublished - 2007 Jul 1

Keywords

  • Allergic rhinitis
  • Protease-activated receptor

ASJC Scopus subject areas

  • Otorhinolaryngology

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