Update on newer antihypertensive medicines

Research output: Contribution to journalArticle

Abstract

The majority of hypertensive patients do not achieve target blood pressure for a variety of reasons, including insufficient medication, drug resistance, and noncompliance. There remains a significant need to develop new agents to better control hypertension. Nebivolol is a third-generation β-adrenergic receptor blocker which is very highly cardioselective and has direct vasodilator properties via stimulation of endothelial nitric oxide synthase activity. Aliskiren is the first orally active inhibitor of renin as an antihypertensive agent. It is associated with dose-related fells in blood pressure comparable to other major classes of antihypertensive drugs with a placebo level of side effects. Endothelin is a powerful vasoconstrictor peptide. An endothelin-receptor antagonist such as bosentan significantly lowered blood pressure in patients with essential hypertension. Vasopep-tidase inhibitors inhibit neutral endopeptidase and angiotensin converting enzymes, but side-effects such as angio-oedema and cough remain to be overcome. AngQb vaccine in hypertensive patients showed a marked reduction in early morning blood pressure without serious adverse events.

Original languageEnglish
Pages (from-to)717-722
Number of pages6
JournalJournal of the Korean Medical Association
Volume53
Issue number8
DOIs
Publication statusPublished - 2010 Aug 1

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Antihypertensive Agents
Blood Pressure
Nebivolol
Neprilysin
Adrenergic Antagonists
Nitric Oxide Synthase Type III
Endothelins
Vasoconstrictor Agents
Peptidyl-Dipeptidase A
Vasodilator Agents
Cough
Drug Resistance
Renin
Adrenergic Receptors
Edema
Vaccines
Placebos
Hypertension
Peptides

Keywords

  • Antihypertensives
  • Drug effects
  • Hypertension
  • Rennin-angiotensin system

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Update on newer antihypertensive medicines. / Park, Chang Gyu.

In: Journal of the Korean Medical Association, Vol. 53, No. 8, 01.08.2010, p. 717-722.

Research output: Contribution to journalArticle

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