Upf1: From mrna surveillance to protein quality control

Hyun Jung Hwang, Yeonkyoung Park, Yoon Ki Kim

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Selective recognition and removal of faulty transcripts and misfolded polypeptides are crucial for cell viability. In eukaryotic cells, nonsense-mediated mRNA decay (NMD) constitutes an mRNA surveillance pathway for sensing and degrading aberrant transcripts harboring premature termination codons (PTCs). NMD functions also as a post-transcriptional gene regulatory mechanism by downregulating naturally occurring mRNAs. As NMD is activated only after a ribosome reaches a PTC, PTC-containing mRNAs inevitably produce truncated and potentially misfolded polypeptides as byproducts. To cope with the emergence of misfolded polypeptides, eukaryotic cells have evolved sophisticated mechanisms such as chaperone-mediated protein refolding, rapid degradation of misfolded polypeptides through the ubiquitin–proteasome system, and sequestration of misfolded polypeptides to the aggresome for autophagy-mediated degradation. In this review, we discuss how UPF1, a key NMD factor, contributes to the selective removal of faulty transcripts via NMD at the molecular level. We then highlight recent advances on UPF1-mediated communication between mRNA surveillance and protein quality control.

Original languageEnglish
Article number995
JournalBiomedicines
Volume9
Issue number8
DOIs
Publication statusPublished - 2021

Keywords

  • Aggresome
  • CTIF
  • MRNA surveillance
  • Nonsense-mediated mRNA decay
  • Protein quality control
  • UPF1

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

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