Urban rodent surveillance, climatic association, and genomic characterization of Seoul virus collected at U.S. army garrison, Seoul, Republic of Korea, 2006-2010

Heung Chul Kim, Won Keun Kim, Jin Sun No, Seung Ho Lee, Se Hun Gu, Sung Tae Chong, Terry A. Klein, Jin Won Song

Research output: Contribution to journalArticle

Abstract

Rodent-borne pathogens pose a critical public health threat in urban areas. An epidemiological survey of urban rodents was conducted from 2006 to 2010 at the U.S. Army Garrison (USAG), Seoul, Republic of Korea (ROK), to determine the prevalence of Seoul virus (SEOV), a rodent-borne hantavirus. A total of 1,950 rodents were captured at USAG, Yongsan, near/in 19.4% (234/1,206) of the numbered buildings. Annual mean rodent infestation rates were the highest for food service facilities, e.g., the Dragon Hill Lodge complex (38.0 rodents) and the Hartell House (18.8 rodents). The brown rat, Rattus norvegicus, accounted for 99.4% (1,939/1,950) of all the rodents captured in the urban area, whereas only 0.6% (11/1,950) of the rodents was house mice (Mus musculus). In November 2006, higher numbers of rats captured were likely associated with climatic factors, e.g., rainfall and temperatures as rats sought harborage in and around buildings. Only 4.7% (34/718) of the rodents assayed for hantaviruses was serologically positive for SEOV. A total of 8.8% (3/34) R. norvegicus were positive for SEOV RNA by reverse transcription polymerase chain reaction, of which two SEOV strains were completely sequenced and characterized. The 39 and 59 terminal sequences revealed incomplete complementary genomic configuration. Seoul virus strains Rn10-134 and Rn10-145 formed a monophyletic lineage with the prototype SEOV strain 80-39. Seoul virus Medium segment showed the highest evolutionary rates compared with the Large and Small segments. In conclusion, this report provides significant insights into continued rodent-borne disease surveillance programs that identify hantaviruses for analysis of disease risk assessments and development of mitigation strategies.

Original languageEnglish
Pages (from-to)470-476
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume99
Issue number2
DOIs
Publication statusPublished - 2018 Jan 1

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Seoul virus
Republic of Korea
Rodentia
Hantavirus
Rodent Diseases
Seoul
Food Services
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ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

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Urban rodent surveillance, climatic association, and genomic characterization of Seoul virus collected at U.S. army garrison, Seoul, Republic of Korea, 2006-2010. / Kim, Heung Chul; Kim, Won Keun; No, Jin Sun; Lee, Seung Ho; Gu, Se Hun; Chong, Sung Tae; Klein, Terry A.; Song, Jin Won.

In: American Journal of Tropical Medicine and Hygiene, Vol. 99, No. 2, 01.01.2018, p. 470-476.

Research output: Contribution to journalArticle

Kim, Heung Chul ; Kim, Won Keun ; No, Jin Sun ; Lee, Seung Ho ; Gu, Se Hun ; Chong, Sung Tae ; Klein, Terry A. ; Song, Jin Won. / Urban rodent surveillance, climatic association, and genomic characterization of Seoul virus collected at U.S. army garrison, Seoul, Republic of Korea, 2006-2010. In: American Journal of Tropical Medicine and Hygiene. 2018 ; Vol. 99, No. 2. pp. 470-476.
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abstract = "Rodent-borne pathogens pose a critical public health threat in urban areas. An epidemiological survey of urban rodents was conducted from 2006 to 2010 at the U.S. Army Garrison (USAG), Seoul, Republic of Korea (ROK), to determine the prevalence of Seoul virus (SEOV), a rodent-borne hantavirus. A total of 1,950 rodents were captured at USAG, Yongsan, near/in 19.4{\%} (234/1,206) of the numbered buildings. Annual mean rodent infestation rates were the highest for food service facilities, e.g., the Dragon Hill Lodge complex (38.0 rodents) and the Hartell House (18.8 rodents). The brown rat, Rattus norvegicus, accounted for 99.4{\%} (1,939/1,950) of all the rodents captured in the urban area, whereas only 0.6{\%} (11/1,950) of the rodents was house mice (Mus musculus). In November 2006, higher numbers of rats captured were likely associated with climatic factors, e.g., rainfall and temperatures as rats sought harborage in and around buildings. Only 4.7{\%} (34/718) of the rodents assayed for hantaviruses was serologically positive for SEOV. A total of 8.8{\%} (3/34) R. norvegicus were positive for SEOV RNA by reverse transcription polymerase chain reaction, of which two SEOV strains were completely sequenced and characterized. The 39 and 59 terminal sequences revealed incomplete complementary genomic configuration. Seoul virus strains Rn10-134 and Rn10-145 formed a monophyletic lineage with the prototype SEOV strain 80-39. Seoul virus Medium segment showed the highest evolutionary rates compared with the Large and Small segments. In conclusion, this report provides significant insights into continued rodent-borne disease surveillance programs that identify hantaviruses for analysis of disease risk assessments and development of mitigation strategies.",
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