Urchin-shaped manganese oxide nanoparticles as pH-responsive activatable T 1 contrast agents for magnetic resonance imaging

Taekhoon Kim, Eun Jin Cho, Youngjoo Chae, Minsik Kim, Aram Oh, Juhong Jin, Eun Sook Lee, Hionsuck Baik, Seungjoo Haam, Jin Suck Suh, Yong Min Huh, Kwangyeol Lee

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Image enhancement: Core-shell MnO@Mn 3O 4 urchin-shaped nanoparticles can be synthesized by means of an anisotropic etching process and used as a pH-activatable T 1 contrast agent for magnetic resonance imaging. The manganese ions released from the MnO phase in the low-pH sites within tumor cells lead to an enhanced T 1 contrast image for the entire tumor mass.

Original languageEnglish
Pages (from-to)10589-10593
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number45
DOIs
Publication statusPublished - 2011 Nov 4

Fingerprint

Manganese oxide
Magnetic resonance
Contrast Media
Tumors
Nanoparticles
Imaging techniques
Anisotropic etching
Image enhancement
Manganese
Cells
Ions
manganese oxide

Keywords

  • anisotropic etching
  • crystal growth
  • magnetic resonance imaging
  • manganese
  • nanoparticles

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Urchin-shaped manganese oxide nanoparticles as pH-responsive activatable T 1 contrast agents for magnetic resonance imaging. / Kim, Taekhoon; Cho, Eun Jin; Chae, Youngjoo; Kim, Minsik; Oh, Aram; Jin, Juhong; Lee, Eun Sook; Baik, Hionsuck; Haam, Seungjoo; Suh, Jin Suck; Huh, Yong Min; Lee, Kwangyeol.

In: Angewandte Chemie - International Edition, Vol. 50, No. 45, 04.11.2011, p. 10589-10593.

Research output: Contribution to journalArticle

Kim, Taekhoon ; Cho, Eun Jin ; Chae, Youngjoo ; Kim, Minsik ; Oh, Aram ; Jin, Juhong ; Lee, Eun Sook ; Baik, Hionsuck ; Haam, Seungjoo ; Suh, Jin Suck ; Huh, Yong Min ; Lee, Kwangyeol. / Urchin-shaped manganese oxide nanoparticles as pH-responsive activatable T 1 contrast agents for magnetic resonance imaging. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 45. pp. 10589-10593.
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