Urchin-shaped manganese oxide nanoparticles as pH-responsive activatable T 1 contrast agents for magnetic resonance imaging

Taekhoon Kim, Eun Jin Cho, Youngjoo Chae, Minsik Kim, Aram Oh, Juhong Jin, Eun Sook Lee, Hionsuck Baik, Seungjoo Haam, Jin Suck Suh, Yong Min Huh, Kwangyeol Lee

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104 Citations (Scopus)

Abstract

Image enhancement: Core-shell MnO@Mn 3O 4 urchin-shaped nanoparticles can be synthesized by means of an anisotropic etching process and used as a pH-activatable T 1 contrast agent for magnetic resonance imaging. The manganese ions released from the MnO phase in the low-pH sites within tumor cells lead to an enhanced T 1 contrast image for the entire tumor mass.

Original languageEnglish
Pages (from-to)10589-10593
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number45
DOIs
Publication statusPublished - 2011 Nov 4

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Keywords

  • anisotropic etching
  • crystal growth
  • magnetic resonance imaging
  • manganese
  • nanoparticles

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Kim, T., Cho, E. J., Chae, Y., Kim, M., Oh, A., Jin, J., Lee, E. S., Baik, H., Haam, S., Suh, J. S., Huh, Y. M., & Lee, K. (2011). Urchin-shaped manganese oxide nanoparticles as pH-responsive activatable T 1 contrast agents for magnetic resonance imaging. Angewandte Chemie - International Edition, 50(45), 10589-10593. https://doi.org/10.1002/anie.201103108