Abstract
Objective: This study aimed to examine whether the uric acid level or gout is causally associated with bone mineral density (BMD). Method: We performed a two-sample Mendelian randomization (MR) analysis. The statistics dataset, we used was from a meta-analysis of genome-wide association studies (GWASs) on uric acid levels from 14 studies with a total of 28 141 participants of European descent, and the dataset for gout from the United Kingdom (UK) Biobank (4807 cases and 3 32 352 controls). We further used the summary statistics dataset of a GWAS on lumbar spine and femur neck (FN) BMDs of individuals of European ancestry (up to 32 735). Results: The instrumental variables (IVs) selected were six single nucleotide polymorphisms (SNPs) from the uric acid level GWAS data and 19 SNPs from the gout GWAS data. The inverse-variance weighted (IVW) method yielded no evidence to support a causal association between the uric acid level or gout and lumbar spine BMD (β = −.002, standard error (SE) = 0.035, P =.951; β = –.700, SE = 0.672, P =.297). MR-Egger regression revealed no causality between uric acid level, gout and lumbar spine. Similarly, the weighted median approach provided no evidence of causality between uric acid level, gout and lumbar spine BMD. The MR results on FN BMD showed similar patterns with those of the lumbar spine BMD. Conclusions: Mendelian randomization analysis did not support a causal association between uric acid level, gout and lumbar spine or FN BMD.
| Original language | English |
|---|---|
| Article number | e13156 |
| Journal | European Journal of Clinical Investigation |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
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Keywords
- BMD
- gout
- Mendelian randomization
- uric acid level
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
Cite this
Uric acid level, gout and bone mineral density : A Mendelian randomization study. / Lee, Young Ho; Song, Gwan Gyu.
In: European Journal of Clinical Investigation, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Uric acid level, gout and bone mineral density
T2 - A Mendelian randomization study
AU - Lee, Young Ho
AU - Song, Gwan Gyu
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Objective: This study aimed to examine whether the uric acid level or gout is causally associated with bone mineral density (BMD). Method: We performed a two-sample Mendelian randomization (MR) analysis. The statistics dataset, we used was from a meta-analysis of genome-wide association studies (GWASs) on uric acid levels from 14 studies with a total of 28 141 participants of European descent, and the dataset for gout from the United Kingdom (UK) Biobank (4807 cases and 3 32 352 controls). We further used the summary statistics dataset of a GWAS on lumbar spine and femur neck (FN) BMDs of individuals of European ancestry (up to 32 735). Results: The instrumental variables (IVs) selected were six single nucleotide polymorphisms (SNPs) from the uric acid level GWAS data and 19 SNPs from the gout GWAS data. The inverse-variance weighted (IVW) method yielded no evidence to support a causal association between the uric acid level or gout and lumbar spine BMD (β = −.002, standard error (SE) = 0.035, P =.951; β = –.700, SE = 0.672, P =.297). MR-Egger regression revealed no causality between uric acid level, gout and lumbar spine. Similarly, the weighted median approach provided no evidence of causality between uric acid level, gout and lumbar spine BMD. The MR results on FN BMD showed similar patterns with those of the lumbar spine BMD. Conclusions: Mendelian randomization analysis did not support a causal association between uric acid level, gout and lumbar spine or FN BMD.
AB - Objective: This study aimed to examine whether the uric acid level or gout is causally associated with bone mineral density (BMD). Method: We performed a two-sample Mendelian randomization (MR) analysis. The statistics dataset, we used was from a meta-analysis of genome-wide association studies (GWASs) on uric acid levels from 14 studies with a total of 28 141 participants of European descent, and the dataset for gout from the United Kingdom (UK) Biobank (4807 cases and 3 32 352 controls). We further used the summary statistics dataset of a GWAS on lumbar spine and femur neck (FN) BMDs of individuals of European ancestry (up to 32 735). Results: The instrumental variables (IVs) selected were six single nucleotide polymorphisms (SNPs) from the uric acid level GWAS data and 19 SNPs from the gout GWAS data. The inverse-variance weighted (IVW) method yielded no evidence to support a causal association between the uric acid level or gout and lumbar spine BMD (β = −.002, standard error (SE) = 0.035, P =.951; β = –.700, SE = 0.672, P =.297). MR-Egger regression revealed no causality between uric acid level, gout and lumbar spine. Similarly, the weighted median approach provided no evidence of causality between uric acid level, gout and lumbar spine BMD. The MR results on FN BMD showed similar patterns with those of the lumbar spine BMD. Conclusions: Mendelian randomization analysis did not support a causal association between uric acid level, gout and lumbar spine or FN BMD.
KW - BMD
KW - gout
KW - Mendelian randomization
KW - uric acid level
UR - http://www.scopus.com/inward/record.url?scp=85070061395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070061395&partnerID=8YFLogxK
U2 - 10.1111/eci.13156
DO - 10.1111/eci.13156
M3 - Article
C2 - 31294819
AN - SCOPUS:85070061395
JO - European Journal of Clinical Investigation
JF - European Journal of Clinical Investigation
SN - 0014-2972
M1 - e13156
ER -