Uridine-based paramagnetic supramolecular nanoaggregate with high relaxivity capable of detecting primitive liver tumor lesions

Sankarprasad Bhuniya, Hyeyoung Moon, Hyunseung Lee, Kwan Soo Hong, Sumin Lee, Dae Yeul Yu, Jong Seung Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The water soluble uridine-based paramagnetic self-assembled amphiphilic molecules (LGd2-5) with DTTA binding site were synthesized and have been characterized in regard to their T1 magnetic resonance imaging (MRI) contrast agent (CA) properties. The water proton relaxivities have been measured in phosphate buffered saline (PBS) at 36 °C at 3 different magnetic fields. Among the self-assembled CAs, LGd3 showed unprecedented, high relaxivities of 30.3 and 23.4 mM-1 s-1 in PBS solution at 36 °C at 0.47 and 1.41 T, respectively. The non-covalent interactions between the new CAs and human serum albumin (HSA) have been investigated and the relaxivity was further increased by 135-215% depending on alkyl chain lengths. The chemically inertness of these complexes (LGd1, LGd2, LGd3, LGd4) against biologically most abundant metal ion (i.e. Zn2+) have shown within the range of commercial DTPA-based CAs. In vivo pharmacokinetics of the complex LGd3 showed highly specific for hepatocytes resulting in increase of contrast noise ratio by ∼240% in T1-weighted MR images of mouse liver 2 h after injection of the LGd3. It is capable to detect small hepatocellular carcinoma (HCC) with diameter of 1.5 mm.

Original languageEnglish
Pages (from-to)6533-6540
Number of pages8
JournalBiomaterials
Volume32
Issue number27
DOIs
Publication statusPublished - 2011 Sep 1

Fingerprint

Uridine
Liver
Tumors
Phosphates
Pentetic Acid
Pharmacokinetics
Water
Binding sites
Magnetic resonance
Magnetic Fields
Chain length
Sodium Chloride
Serum Albumin
Contrast Media
Metal ions
Noise
Protons
Hepatocytes
Hepatocellular Carcinoma
Neoplasms

Keywords

  • Complexation
  • Gadolinium Gd
  • Magnetic resonance imaging (MRI)
  • Relaxivity
  • Transmetallation
  • Uridine

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

Cite this

Uridine-based paramagnetic supramolecular nanoaggregate with high relaxivity capable of detecting primitive liver tumor lesions. / Bhuniya, Sankarprasad; Moon, Hyeyoung; Lee, Hyunseung; Hong, Kwan Soo; Lee, Sumin; Yu, Dae Yeul; Kim, Jong Seung.

In: Biomaterials, Vol. 32, No. 27, 01.09.2011, p. 6533-6540.

Research output: Contribution to journalArticle

Bhuniya, Sankarprasad ; Moon, Hyeyoung ; Lee, Hyunseung ; Hong, Kwan Soo ; Lee, Sumin ; Yu, Dae Yeul ; Kim, Jong Seung. / Uridine-based paramagnetic supramolecular nanoaggregate with high relaxivity capable of detecting primitive liver tumor lesions. In: Biomaterials. 2011 ; Vol. 32, No. 27. pp. 6533-6540.
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